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Peptide record

TPDB40783

CLT2 Anticancer Tumor-homing Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB40783
CLT2
Anticancer Tumor-homing Peptides
Cancer-related peptides
Peptipedia StackTHP StackTHPred TumorHoPe2.0
standard
No
A 10-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.
Sequence
CNAGESSKNC
Physicochemical Analysis
C36H61N13O17S2
RDQHILMFPTWYV
NCS
1012.08
6.14
1
1
1
-0
3.47
-0.960
10.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
12.35
6
Residue Composition
number
1
A
0
R
2
N
0
D
2
C
1
E
0
Q
1
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 2 D: 0 C: 2 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C36H61N13O17S2
1012.08
6.14
-0
3.47
-0.960
Evidence Records 2 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Fibrillar meshwork in the extracellular compartment of the tumors
Homing
Multiple tumor

Source & Reference

TumorHoPe2.0
TumorHoPe2
Peptides selected for binding to clotted plasma accumulate in tumor stroma and wounds
2006
Pilch J et al. Proc Natl Acad Sci U S A. 2006 Feb 21 103(8):2800-4.
US 2009/0214429A1

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Human patient biopsies
C57BL/6 mice bearing B16F1 tumors, B16F1 mouse melanoma, Lewis lung carcinoma, C8161 human melanoma, MDA-MB-435 human breast cancer, and PPC-1 human prostate cancer
Phage display library
T7phage/CX8C peptide library
Fluorescein conjugates
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell,
Homing
gC1q/p32 receptor

Source & Reference

TumorHoPe2.0
TumorHoPe2
Targeted delivery system and methods of use therefor
2022
US 11512110 B2
US 11512110 B2

Other

Athymic nude mice, ApoE null mice
Phage display library
T7 phage / cyclic Cx7C and linear X7 peptide library
Nanoworms(NWs), polyethylene glycol
Additional Detail Fields 4 fields
Fluorescein conjugates Nanoworms(NWs), polyethylene glycol
Human patient biopsies
C57BL/6 mice bearing B16F1 tumors, B16F1 mouse melanoma, Lewis lung carcinoma, C8161 human melanoma, MDA-MB-435 human breast cancer, and PPC-1 human prostate cancer Athymic nude mice, ApoE null mice
T7phage/CX8C peptide library T7 phage / cyclic Cx7C and linear X7 peptide library