TPDB

3D PDB MODEL

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TPDB ID TPDB40777

Peptide_Name

PSP1

Activity

Anticancer Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

Peptipedia StackTHP StackTHPred TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 9-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.

Sequence

CLSYYPSYC

FASTA

>TPDB40777|Anticancer;Tumor-homing Peptides|length=9
CLSYYPSYC

Formula C50H67N9O15S2

Absent Amino Acids ARNDEQGHIKMFTWV

Common Amino Acids Y

Mass 1098.25

PI 5.17

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 4

Net Charge -0

Boman Index -3.15

Hydrophobicity 0.189

Aliphatic Index 43.33

Half Life

Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 4595

Absorbance 280nm 418.39

Polar Residues 7

number

0

A

0

R

0

N

0

D

2

C

0

E

0

Q

0

G

0

H

0

I

1

L

0

K

0

M

0

F

1

P

2

S

0

T

0

W

3

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 2 T: 0 W: 0 Y: 3 V: 0

Length

9

Formula

C50H67N9O15S2

Mass

1098.25

PI

5.17

Net Charge

-0

Boman Index

-3.15

Hydrophobicity

0.189

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Homing or Targeting Homing

Target Tumor Lung cancer

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Apoptosis imaging: beyond annexin V.

Year 2010

Reference

Niu G et al. J Nucl Med. 2010 Nov 51(11):1659-62.

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVivo Model Tumor-bearing nude mice (H460-cell xenograft model)

Source Type Synthetic

Phage Display Library M13 phage /9- mer peptide library

Conjugate Payload FITC, camptothecin

Evidence 2 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell

Homing or Targeting Homing

Target Tumor Lung cancer

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title

Advantages of the phosphatidylserine-recognizing peptide PSP1 for molecular imaging of tumor apoptosis compared with annexin V

Year 2015

Reference

Kim S et al. PLoS One. 2015 Mar 24 10(3):e0121171.

Other

InVitro ExVivo H460 cell

InVivo Model 6-wk-old female BALB/c nude mice

Source Type Phage Display Library

Phage Display Library M13 phage

Conjugate Payload camptothecin

Conjugate_Payload

FITC, camptothecin camptothecin

InVitro_ExVivo

H460 cell

InVivo_Model

Tumor-bearing nude mice (H460-cell xenograft model) 6-wk-old female BALB/c nude mice

Phage_Display_Library

M13 phage /9- mer peptide library M13 phage