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Peptide record

TPDB40774

LSD Anticancer Tumor-homing Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB40774
LSD
Anticancer Tumor-homing Peptides
Cancer-related peptides
Peptipedia StackTHP StackTHPred TumorHoPe2.0
standard
No
A 9-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.
Sequence
CLSDGKRKC
Physicochemical Analysis
C39H72N14O13S2
ANEQHIMFPTWYV
CK
1009.21
9.11
3
1
1
+2
3.12
-0.911
43.33
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
12.39
3
Residue Composition
number
0
A
1
R
0
N
1
D
2
C
0
E
0
Q
1
G
0
H
0
I
1
L
2
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 2 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C39H72N14O13S2
1009.21
9.11
+2
3.12
-0.911
Evidence Records 2 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Lymphatic vessel
Homing
Human melanoma
Podoplanin, Prox-1,LYVE-1 and VEGFR-10

Source & Reference

TumorHoPe2.0
TumorHoPe2
Lymphatic zip codes in premalignant lesions and tumors
2006
Zhang L et al. Cancer Res. 2006 Jun 1 66(11):5696-706.
US 2007/0219134A1

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
C8161 human melanoma, MDA-MB-435 human breast cancer
Mice bearing C8161 cells human cancer xenografts
Phage display library
T7 phage/CX7C peptide library
Radioactive indium, proapoptotic peptide
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Lung cancer, Breast cancer, Liver cancer, Melanoma, stomach cancer, Pancreatic cancer, Colorectal cancer, Ovarian cancer, Renal cell carcinoma, Prostate cancer, Brain tumor

Source & Reference

TumorHoPe2.0
TumorHoPe2
Noxa-derived, cell death-inducing peptide eMTD
2022
US 11248024 B2
US 11248024 B2

Other

Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line
6-week-old BalB/C mice
Synthetic
necrosis-inducing peptide, Fluorescein (FAM)
Additional Detail Fields 4 fields
Radioactive indium, proapoptotic peptide necrosis-inducing peptide, Fluorescein (FAM)
C8161 human melanoma, MDA-MB-435 human breast cancer Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line
Mice bearing C8161 cells human cancer xenografts 6-week-old BalB/C mice
T7 phage/CX7C peptide library