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Peptide record

TPDB40756

KAA Anticancer Tumor-homing Peptides standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB40756
KAA
Anticancer Tumor-homing Peptides
Cancer-related peptides
Peptipedia StackTHP StackTHPred TumorHoPe2.0
standard
No
A 7-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.
Sequence
CKAAKNK
Physicochemical Analysis
C31H59N11O9S1
RDEQGHILMFPSTWYV
K
761.94
10.32
3
0
2
+3
2.81
-1.300
28.57
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
2
A
0
R
1
N
0
D
1
C
0
E
0
Q
0
G
0
H
0
I
0
L
3
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C31H59N11O9S1
761.94
10.32
+3
2.81
-1.300
CKA-K CendR
Evidence Records 4 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Endothelial cellor pericytes
Homing
Pancreatic islet carcinoma

Source & Reference

TumorHoPe2.0
TumorHoPe2
Stage-specific vascular markers revealed by phage display in a mouse model of pancreatic islet tumorigenesis
2003
Joyce JA et al. Cancer Cell. 2003 Nov 4(5):393-403.
US 2005/0245445A1

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Prototypical mouse model of multistage tumorigenesis, RIP1-Tag2 transgenic model of islet cell carcinoma and K14-HPV16 mice
Phage display library
T7 phage/CX7C peptide library
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell,
Homing
Pancreatic cancer
gC1q/p32 receptor

Source & Reference

TumorHoPe2.0
TumorHoPe2
Targeted delivery system and methods of use therefor
2022
US 11512110 B2
US 11512110 B2

Other

Athymic nude mice, ApoE null mice
Phage display library
T7 phage / cyclic Cx7C and linear X7 peptide library
Nanoworms(NWs), polyethylene glycol
Evidence 3 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell,
Homing
gC1q/p32 receptor

Source & Reference

TumorHoPe2.0
TumorHoPe2
Targeted delivery system and methods of use therefor
2022
US 11512110 B2
US 11512110 B2

Other

Athymic nude mice, ApoE null mice
Phage display library
T7 phage / cyclic Cx7C and linear X7 peptide library
Nanoworms(NWs), polyethylene glycol
Evidence 4 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell, Epithelial cell, Dendritic cell
Homing
Pancreatic cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
Methods and compositions using peptides and proteins with C-terminal elements
2019
US 10370245 B2
US 10370245 B2

Other

PPC-1, PC-3, Du-145, 4T1, MIA PaCa-2, PDAC1.3, B16F10, M21, and MDA-MB-435 cell line
BALB/c athymic nude mice
Phage Display library
T7 phage display library
nanoparticles, nanoworms, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)2000 DSPE-PEG2000-maleimide]
Additional Detail Fields 4 fields
Nanoworms(NWs), polyethylene glycol nanoparticles, nanoworms, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)2000 DSPE-PEG2000-maleimide]
PPC-1, PC-3, Du-145, 4T1, MIA PaCa-2, PDAC1.3, B16F10, M21, and MDA-MB-435 cell line
Prototypical mouse model of multistage tumorigenesis, RIP1-Tag2 transgenic model of islet cell carcinoma and K14-HPV16 mice Athymic nude mice, ApoE null mice BALB/c athymic nude mice
T7 phage/CX7C peptide library T7 phage / cyclic Cx7C and linear X7 peptide library T7 phage display library