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Peptide record

TPDB40725

GX1 Anticancer Tumor-homing Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB40725
GX1
Anticancer Tumor-homing Peptides
Cancer-related peptides
Peptipedia StackTHP StackTHPred TumorHoPe2.0
standard
No
A 9-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.
Sequence
CGNSNPKSC
Physicochemical Analysis
C33H56N12O14S2
ARDEQHILMFTWYV
NCS
909.00
8.29
1
0
0
+1
2.07
-1.056
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
13.75
6
Residue Composition
number
0
A
0
R
2
N
0
D
2
C
0
E
0
Q
1
G
0
H
0
I
0
L
1
K
0
M
0
F
1
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 2 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 1 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C33H56N12O14S2
909.00
8.29
+1
2.07
-1.056
Evidence Records 4 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Endothelial cell
Homing
Gastric cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
Characterization of a specific phage-displayed Peptide binding to vasculature of human gastric cancer
2004
Zhi M et al. Cancer Biol Ther. 2004 Dec 3(12):1232-5.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Human umbilical vein endothelial cells( HUVEC), lovo cells, Hep-g2 cells, SGC-7901 cells, Eca-109 cells
2 month old Balb/c mice of human xenograft of gastric cancer
Phage display library
T7 phage/C7C peptide library
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Endothelial cell
Homing
Gastric cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
A novel peptide (GX1) homing to gastric cancer vasculature inhibits angiogenesis and cooperates with TNF alpha in anti-tumor therapy
2009
Chen B et al. BMC Cell Biol. 2009 Sep 9 10:63.
CN1580075, CN1872880

Other

HUVEC cultured in tumor-conditioned medium,Gastric cancer cell line SGC7901
Nude mice
Phage display library
GX1-rmhTNF alpha labeled with 99TcmO4, Antitumor cytokine rmhTNF alpha
Evidence 3 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Lung cancer, Breast cancer, Liver cancer, Melanoma, stomach cancer, Pancreatic cancer, Colorectal cancer, Ovarian cancer, Renal cell carcinoma, Prostate cancer, Brain tumor

Source & Reference

TumorHoPe2.0
TumorHoPe2
Noxa-derived, cell death-inducing peptide eMTD
2022
US 11248024 B2
US 11248024 B2

Other

Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line
6-week-old BalB/C mice
Synthetic
necrosis-inducing peptide, Fluorescein (FAM)
Evidence 4 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, endothelial cell, Tumor vasculature
Targeting
Gastric cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
GX1 targeting delivery of rmhTNFα evaluated using multimodality imaging
2014
Hao Hu et al. Int J Pharm. 2014 Jan 30 461(1-2):181-91.

Other

Human umbilical vein endothelial cells (HUVECs), co-cultured HUVECs (co-HUVECs), SGC7901 gastric cancer cells, immortal gastric epithelial cells (GES-1), SV40 large T-antigen transformed HEK-293 cells (293T), human gastric SGC7901 cancer cell line
Female athymic BALB/c mice (4-6 weeks old)
Synthetic
Recombinant mutant human TNFα (rmhTNFα), 99mTc (Technetium-99m)
Additional Detail Fields 4 fields
GX1-rmhTNF alpha labeled with 99TcmO4, Antitumor cytokine rmhTNF alpha necrosis-inducing peptide, Fluorescein (FAM) Recombinant mutant human TNFα (rmhTNFα), 99mTc (Technetium-99m)
Human umbilical vein endothelial cells( HUVEC), lovo cells, Hep-g2 cells, SGC-7901 cells, Eca-109 cells HUVEC cultured in tumor-conditioned medium,Gastric cancer cell line SGC7901 Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line Human umbilical vein endothelial cells (HUVECs), co-cultured HUVECs (co-HUVECs), SGC7901 gastric cancer cells, immortal gastric epithelial cells (GES-1), SV40 large T-antigen transformed HEK-293 cells (293T), human gastric SGC7901 cancer cell line
2 month old Balb/c mice of human xenograft of gastric cancer Nude mice 6-week-old BalB/C mice Female athymic BALB/c mice (4-6 weeks old)
T7 phage/C7C peptide library