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Peptide record

TPDB40724

Ad-Mda-tlyp1 Lyp-1 Lyp1 Anticancer Cell-penetrating Peptides Tumor-homing Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB40724
Ad-Mda-tlyp1 Lyp-1 Lyp1
Anticancer Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
Peptipedia CellPPD CellPPD-MOD CPPsite3.0 MLCPP 2.0 PerseuCPP StackTHP StackTHPred TumorHoPe2.0
standard
No
A 9-aa standard natural multi-activity (Anticancer, Cell-penetrating Peptides, and Tumor-homing Peptides) peptide sequence curated from Peptipedia, CellPPD, CellPPD-MOD, and other sources, with an available 3D structural model.
Sequence
CGNKRTRGC
Physicochemical Analysis
C36H67N17O12S2
ADEQHILMFPSWYV
RCG
994.15
10.12
3
0
0
+3
2.71
-1.433
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
12.57
4
Residue Composition
number
0
A
2
R
1
N
0
D
2
C
0
E
0
Q
2
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C36H67N17O12S2
994.15
10.12
+3
2.71
-1.433
CendR (R/K)XX(R/K)
Evidence Records 17 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Lymphatic vessel
Homing (Phage display clone)
Breast cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
Peptides that home to tumor lymphatic vasculature and methods of using same
2007
U.S. Pat. No. 7192921

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
MDA-MB-435 breast carcinoma cell line
HIFko tumor-bearing mice
Phage display library
T7 phage / random peptide library
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Breast cancer, Ovarian cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
Compositions for treating cancer and methods for making the same
2019
US 10300143 B2
US 10300143 B2

Other

4T1 breast cancer cell line, MDA-MB-468 breast cancer cell line, 4306-ovarian cancer cell line, Lewis lung carcinoma (LLC) cells, hepatocellular carcinoma cells (CP20)
BALB/c mice
Synthetic
diacylglycerols, dialkylglycerols
Evidence 3 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell,
Homing
gC1q/p32 receptor

Source & Reference

TumorHoPe2.0
TumorHoPe2
Targeted delivery system and methods of use therefor
2022
US 11512110 B2
US 11512110 B2

Other

Athymic nude mice, ApoE null mice
Phage display library
T7 phage / cyclic Cx7C and linear X7 peptide library
Nanoworms(NWs), polyethylene glycol
Evidence 4 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Lung cancer, Breast cancer, Liver cancer, Melanoma, stomach cancer, Pancreatic cancer, Colorectal cancer, Ovarian cancer, Renal cell carcinoma, Prostate cancer, Brain tumor

Source & Reference

TumorHoPe2.0
TumorHoPe2
Noxa-derived, cell death-inducing peptide eMTD
2022
US 11248024 B2
US 11248024 B2

Other

Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line
6-week-old BalB/C mice
Synthetic
necrosis-inducing peptide, Fluorescein (FAM)
Evidence 5 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell, Epithelial cell, Dendritic cell
Homing
Lung cancer, Breast cancer, Liver cancer, Melanoma, Pancreatic cancer, Colorectal cancer, Prostate cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
Methods and compositions using peptides and proteins with C-terminal elements
2019
US 10370245 B2
US 10370245 B2

Other

PPC-1, PC-3, Du-145, 4T1, MIA PaCa-2, PDAC1.3, B16F10, M21, and MDA-MB-435 cell line
BALB/c athymic nude mice
Phage Display library
T7 phage display library
nanoparticles, nanoworms, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)2000 DSPE-PEG2000-maleimide]
Evidence 6 Activity

Activity

Tumor-homing Peptides

Target

Tumor lymphatic, Tumor cell, Tumor macrophage, Endothelial cell
Homing
Breast cancer, Prostate cancer
neuropilin-1, receptor p32

Source & Reference

TumorHoPe2.0
TumorHoPe2
Truncated LYP-1 peptides and methods and compositions using truncated LYP-1 peptides
2019
US 10179801 B2
US 10179801 B2

Other

4T1, MDA-MB-435 Breast cancer cell line, DU145, PPC1
BALB/C athymic nude mice
Phage Display library
T7 phage display library
fluorescein-labeled, iron oxide nanoworms
Evidence 7 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Breast cancer, Squamous cell carcinoma, Colon carcinoma
vimentin

Source & Reference

TumorHoPe2.0
TumorHoPe2
Carcinoma homing peptide (CHP), its analogs, and methods of using
2017
US 9657077 B2
US 9657077 B2

Other

SCCVII, CT26, 4T1, and B16F10 cell line
C57B1/6 mice, C3H mice, Nude mice, wtIL-12−/− mice, female Balb/c mice (all are six to eight weeks old)
Phage Display library
interleukin 12 (IL-12)
Evidence 8 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Breast cancer
p32 protein

Source & Reference

TumorHoPe2.0
TumorHoPe2
Mild photothermal therapy/photodynamic therapy/chemotherapy of breast cancer by Lyp-1 modified Docetaxel/IR820 Co-loaded micelles
2016
WenTing Li et al. Biomaterials. 2016 Nov:106:119-33.

Other

4T1 murine breast cancer cell line
Female BALB/c mice (20 ± 2g)
Synthetic
Docetaxel (DTX), IR820, PCL-g-PEI-g-PEG
Evidence 9 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Breast cancer
p32 mitochondrial protein

Source & Reference

TumorHoPe2.0
TumorHoPe2
Design and In Vitro Evaluation of Bispecific Complexes and Drug Conjugates of Anticancer Peptide, LyP-1 in Human Breast Cancer
2017
Selin Seda Timur et al. Pharm Res. 2017 Feb 34(2):352-364.

Other

MDA-MB-231 breast cancer cells
Phage display library
fluorophore-conjugated nano-polymers, Doxorubicin (Dox), Poly-L-lysine, DTPA, Fluorescein
Evidence 10 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Breast cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
Ultrasmall Semimetal Nanoparticles of Bismuth for Dual-Modal Computed Tomography/Photoacoustic Imaging and Synergistic Thermoradiotherapy
2017
Xujiang Yu et al. ACS Nano. 2017 Apr 25 11(4):3990-4001.

Other

4T1 murine breast cancer cells
Six-week-old Balb/c mice
Synthetic
Bismuth nanoparticles (Bi NPs)
Evidence 11 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Breast cancer, Liver cancer, Gastric cancer
neuropilin receptors (NRP1 and NRP2)

Source & Reference

TumorHoPe2.0
TumorHoPe2
The investigation of the death-inducing potency of a recombinant Adenovector expressing Mda-7-tlyp-1 on different cancer cell lines
2024
Fatemeh Vatanparast et al. Gastroenterol Hepatol Bed Bench. 2024. 17(1): 45–56

Other

breast (MCF7), liver (HepG2), and gastric (MKN45), AD293, HEK-293 cancer cell line
Synthetic
Evidence 12 Activity

Activity

Tumor-homing Peptides

Target

Homing

Source & Reference

TumorHoPe2.0
TumorHoPe2
2012
Keiji Numata et al. Macromol Biosci. 2012 Jan 12(1):75-82.
Evidence 13 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, tumor lymphatic, tumor macrophage
Homing
Breast cancer
Neuropilin-1 (NRP1), Neuropilin-2 (NRP2), p32 protein

Source & Reference

TumorHoPe2.0
TumorHoPe2
Transtumoral targeting enabled by a novel neuropilin-binding peptide
2012
L Roth et al. Oncogene. 2012 Aug 16 31(33):3754-63.

Other

MDA-MB-435 breast carcinoma cells, DU145 prostate carcinoma cells
Normal BALB/c mice
Phage display
iron oxide nanoworms
Evidence 14 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Endothelial cell, Tumor vessel
Homing
VEGF, neuropilin-1

Source & Reference

TumorHoPe2.0
TumorHoPe2
Tumor-penetrating peptides
2013
Tambet Teesalu et al. Front Oncol. 2013 Aug 27:3:216.

Other

Phage Display library
doxorubicin
Evidence 15 Activity

Activity

Tumor-homing Peptides

Target

Tumor macrophage, Tumor cell, Endothelial cell
Homing
Breast cancer
Cell surface p32

Source & Reference

TumorHoPe2.0
TumorHoPe2
New p32/gC1qR Ligands for Targeted Tumor Drug Delivery
2016
Lauri Paasonen et al. Chembiochem. 2016 Apr 1 17(7):570-5.

Other

MCF10Ca1A breast Cancer cell line
Phage Display Library
T7 phage CX7C peptide library
Evidence 16 Activity

Activity

Tumor-homing Peptides

Target

Homing

Source & Reference

TumorHoPe2.0
TumorHoPe2
2023
Ludivine Larue et al. Bioorg Chem. 2023 Jan:130:106200.
Evidence 17 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Breast cancer, osteosarcoma, Prostate carcinoma,tumor‐associated macrophages, Atherosclerotic plaques with Metastatic lymph nodes
p32 and gC1qR

Source & Reference

TumorHoPe2.0
TumorHoPe2
The penetrating properties of the tumor homing peptide LyP-1 in model lipid membranes
2019
Cionabasu C et al. J Pept Sci. 2019 Mar 25(3):e3145.

Other

Synthetic
TAMRA
Additional Detail Fields 4 fields
diacylglycerols, dialkylglycerols Nanoworms(NWs), polyethylene glycol necrosis-inducing peptide, Fluorescein (FAM) nanoparticles, nanoworms, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)2000 DSPE-PEG2000-maleimide] fluorescein-labeled, iron oxide nanoworms interleukin 12 (IL-12) Docetaxel (DTX), IR820, PCL-g-PEI-g-PEG fluorophore-conjugated nano-polymers, Doxorubicin (Dox), Poly-L-lysine, DTPA, Fluorescein Bismuth nanoparticles (Bi NPs) iron oxide nanoworms doxorubicin TAMRA
MDA-MB-435 breast carcinoma cell line 4T1 breast cancer cell line, MDA-MB-468 breast cancer cell line, 4306-ovarian cancer cell line, Lewis lung carcinoma (LLC) cells, hepatocellular carcinoma cells (CP20) Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line PPC-1, PC-3, Du-145, 4T1, MIA PaCa-2, PDAC1.3, B16F10, M21, and MDA-MB-435 cell line 4T1, MDA-MB-435 Breast cancer cell line, DU145, PPC1 SCCVII, CT26, 4T1, and B16F10 cell line 4T1 murine breast cancer cell line MDA-MB-231 breast cancer cells 4T1 murine breast cancer cells breast (MCF7), liver (HepG2), and gastric (MKN45), AD293, HEK-293 cancer cell line MDA-MB-435 breast carcinoma cells, DU145 prostate carcinoma cells MCF10Ca1A breast Cancer cell line
HIFko tumor-bearing mice BALB/c mice Athymic nude mice, ApoE null mice 6-week-old BalB/C mice BALB/c athymic nude mice C57B1/6 mice, C3H mice, Nude mice, wtIL-12−/− mice, female Balb/c mice (all are six to eight weeks old) Female BALB/c mice (20 ± 2g) Six-week-old Balb/c mice Normal BALB/c mice
T7 phage / random peptide library T7 phage / cyclic Cx7C and linear X7 peptide library T7 phage display library T7 phage CX7C peptide library