TPDB

3D PDB MODEL

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TPDB ID TPDB40718

Peptide_Name

Decapeptide CLT1

Activity

Anticancer Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

Peptipedia StackTHP StackTHPred TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 10-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.

Sequence

CGLIIQKNEC

FASTA

>TPDB40718|Anticancer;Tumor-homing Peptides|length=10
CGLIIQKNEC

Formula C46H81N13O15S2

Absent Amino Acids ARDHMFPSTWYV

Common Amino Acids CI

Mass 1120.35

PI 6.14

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 3

Net Charge -0

Boman Index 2.36

Hydrophobicity 0.300

Aliphatic Index 117.00

Half Life

Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 11.16

Polar Residues 4

number

0

A

0

R

1

N

0

D

2

C

1

E

1

Q

1

G

0

H

2

I

1

L

1

K

0

M

0

F

0

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 0 C: 2 E: 1 Q: 1 G: 1 H: 0 I: 2 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

10

Formula

C46H81N13O15S2

Mass

1120.35

PI

6.14

Net Charge

-0

Boman Index

2.36

Hydrophobicity

0.300

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Fibrillar meshwork in the extracellular compartment of the tumors

Homing or Targeting Homing

Target Tumor Multiple tumor

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Peptides selected for binding to clotted plasma accumulate in tumor stroma and wounds

Year 2006

Reference

Pilch J et al. Proc Natl Acad Sci U S A. 2006 Feb 21 103(8):2800-4.

Patent US 2009/0214429A1

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo Human patient biopsies

InVivo Model

C57BL/6 mice bearing B16F1 tumors, B16F1 mouse melanoma, Lewis lung carcinoma, C8161 human melanoma, MDA-MB-435 human breast cancer, and PPC-1 human prostate cancer

Source Type Phage display library

Phage Display Library T7phage/CX8C peptide library

Conjugate Payload Fluorescein conjugates

Comments he CLT peptides may be useful as a general imaging or drug delivery agent for tumors, as well as for tissue injuries

Evidence 2 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell,

Homing or Targeting Homing

Receptors Biomarker gC1q/p32 receptor

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Targeted delivery system and methods of use therefor

Year 2022

Reference

US 11512110 B2

Patent US 11512110 B2

Other

InVivo Model Athymic nude mice, ApoE null mice

Source Type Phage display library

Phage Display Library T7 phage / cyclic Cx7C and linear X7 peptide library

Conjugate Payload Nanoworms(NWs), polyethylene glycol

Conjugate_Payload

Fluorescein conjugates Nanoworms(NWs), polyethylene glycol

InVitro_ExVivo

Human patient biopsies

InVivo_Model

C57BL/6 mice bearing B16F1 tumors, B16F1 mouse melanoma, Lewis lung carcinoma, C8161 human melanoma, MDA-MB-435 human breast cancer, and PPC-1 human prostate cancer Athymic nude mice, ApoE null mice

Phage_Display_Library

T7phage/CX8C peptide library T7 phage / cyclic Cx7C and linear X7 peptide library