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Peptide record

TPDB40716

CGKRK-PEG-DSPE Anticancer Blood-Brain Barrier Cell-penetrating Peptides Tumor-homing Peptides standard
5 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB40716
CGKRK-PEG-DSPE
Anticancer Blood-Brain Barrier Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
Peptipedia B3Pred BBPpredict CPPsite3.0 StackTHP StackTHPred TumorHoPe2.0
standard
No
A 5-aa standard natural multi-activity (Anticancer, Blood-Brain Barrier, Cell-penetrating Peptides, and other sources) peptide sequence curated from Peptipedia, B3Pred, BBPpredict, and other sources, with an available 3D structural model.
Sequence
CGKRK
Physicochemical Analysis
C23H46N10O6S1
ANDEQHILMFPSTWYV
K
590.74
10.59
3
0
0
+3
2.56
-2.040
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
1
R
0
N
0
D
1
C
0
E
0
Q
1
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
5
C23H46N10O6S1
590.74
10.59
+3
2.56
-2.040
RGD
Similarity
Evidence Records 9 records
Evidence 1 Activity

Activity

Blood-Brain Barrier

Target

U87MG cells

Assay & Model

Fluorescent microscopy
It exhibited enhanced transportation
Origin/Source
Fluorescence imaging analysis
It penetrated across the BBB to accumulate at tumor sites with the assistance of Bor and active glio
Glioblastoma

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Intravenous
CGKRK-PSNPs combined with borneol could improve the anti-glioma efficacy with the prolonged medium s
Transcytosis
Combined with borneol
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Tumor vessel
Homing
Epidermal squamous cell cancers
MECA32 (Second endothelial marker, the cell-surface antigen)

Source & Reference

TumorHoPe2.0
TumorHoPe2
Progressive vascular changes in a transgenic mouse model of squamous cell carcinoma
2003
Hoffman JA et al. Cancer Cell. 2003 Nov 4(5):383-91.
US 2006/0002854A1

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
K14-HPV16 mice, FVB/b mice , C57B16 cells bearing mice,RIP1-Tag2 mice
Phage display library
T7 phage /9-mer cyclic (CX7C) peptide library
Evidence 3 Activity

Activity

Tumor-homing Peptides

Target

Tumor vessel
Homing
Breast tumor
Heparansulphate

Source & Reference

TumorHoPe2.0
TumorHoPe2
Spider silk-based gene carriers for tumor cell-specific delivery.
2011
Numata K et al .Bioconjug Chem 2011 Aug 17 22(8):1605-10.
US 7,723,474 B2

Other

MDA-MB-435 melanoma cell line, MDA-MB-231
Mice bearing MDA-MB-231
Synthetic
pDNA complexes of silk proteins containing poly(L-lysine)
Evidence 4 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Lung cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
Compositions of a peptide targeting system for treating cancer
2014
US 8680045 B2
US 8680045 B2

Other

SW900, H460, A549
Nude mice (20 g)
Phage display library
Cy5.5
Evidence 5 Activity

Activity

Tumor-homing Peptides

Target

Tumor lymphatic, Tumor cell, Tumor macrophage
Homing
Breast cancer, Prostate cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
Truncated LYP-1 peptides and methods and compositions using truncated LYP-1 peptides
2019
US 10179801 B2
US 10179801 B2

Other

4T1, MDA-MB-435 Breast cancer cell line, DU145, PPC1
BALB/C athymic nude mice
Phage Display library
T7 phage display library
iron oxide nanoworms
Evidence 6 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Liver carcinoma

Source & Reference

TumorHoPe2.0
TumorHoPe2
Optimization and internalization mechanisms of PEGylated adenovirus vector with targeting peptide for cancer gene therapy
2012
Xing-Lei Yao et al. Biomacromolecules. 2012 Aug 13. 13(8)

Other

B16BL6 cells
Five-week-old female C57BL/6 mice
Synthetic
adenovirus vector (Adv)
Evidence 7 Activity

Activity

Tumor-homing Peptides

Target

Tumor vessel
Homing

Source & Reference

TumorHoPe2.0
TumorHoPe2
Optimization and internalization mechanisms of PEGylated adenovirus vector with targeting peptide for cancer gene therapy
2012
Xing-Lei Yao et al. Biomacromolecules. 2012 Aug 13 13(8):2402-9.

Other

B16BL6 (mouse melanoma) cells
Five-week-old female C57BL/6 mice
Synthetic
polyethyleneglycol (PEG), Adv
Evidence 8 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Endothelial cell, Tumor vessel
Targeting
Breast cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
Tumor-Targeted Multimodal Optical Imaging with Versatile Cadmium-Free Quantum Dots
2016
Xiangyou Liu et al. Adv Funct Mater. 2016 Jan 13 26(2):267-276.

Other

MCF10CA1a human breast cancer cells, NG2-positive GFP-CT2A mouse astrocytoma cells
Female BALB/c mice, female athymic nude mice, female C57BL/6 mice
Phage Display Library
cadmium-free CuInSe2/ZnS core/shell
Evidence 9 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Ovarian cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
Tumor-Targeting, MicroRNA-Silencing Porous Silicon Nanoparticles for Ovarian Cancer Therapy
2019
Bertucci A et al.ACS Appl Mater Interfaces. 2019 Jul 10 11(27):23926-23937.

Other

CAOV-3, COV-318, OVCAR-8, Kuramochi, KF-28, IGROV-1, OWA42 cell line
6 weeks old female nude mice, injected with COV-318 cells
Synthetic
LNA-loaded porous silicon nanoparticles(pSiNP)
Additional Detail Fields 5 fields
pDNA complexes of silk proteins containing poly(L-lysine) Cy5.5 iron oxide nanoworms adenovirus vector (Adv) polyethyleneglycol (PEG), Adv cadmium-free CuInSe2/ZnS core/shell LNA-loaded porous silicon nanoparticles(pSiNP)
Intravenous
MDA-MB-435 melanoma cell line, MDA-MB-231 SW900, H460, A549 4T1, MDA-MB-435 Breast cancer cell line, DU145, PPC1 B16BL6 cells B16BL6 (mouse melanoma) cells MCF10CA1a human breast cancer cells, NG2-positive GFP-CT2A mouse astrocytoma cells CAOV-3, COV-318, OVCAR-8, Kuramochi, KF-28, IGROV-1, OWA42 cell line
K14-HPV16 mice, FVB/b mice , C57B16 cells bearing mice,RIP1-Tag2 mice Mice bearing MDA-MB-231 Nude mice (20 g) BALB/C athymic nude mice Five-week-old female C57BL/6 mice Female BALB/c mice, female athymic nude mice, female C57BL/6 mice 6 weeks old female nude mice, injected with COV-318 cells
T7 phage /9-mer cyclic (CX7C) peptide library T7 phage display library