TPDB

3D PDB MODEL

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TPDB ID TPDB40691

Activity

Anticancer Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

Peptipedia StackTHP StackTHPred TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.

Sequence

CDTRL

FASTA

>TPDB40691|Anticancer;Tumor-homing Peptides|length=5
CDTRL

Formula C23H42N8O9S1

Absent Amino Acids ANEQGHIKMFPSWYV

Common Amino Acids RDCLT

Mass 606.69

PI 6.09

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 1

Net Charge -0

Boman Index 1.38

Hydrophobicity -0.480

Aliphatic Index 78.00

Half Life

Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

0

A

1

R

0

N

1

D

1

C

0

E

0

Q

0

G

0

H

0

I

1

L

0

K

0

M

0

F

0

P

0

S

1

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 1 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 0

Length

5

Formula

C23H42N8O9S1

Mass

606.69

PI

6.09

Net Charge

-0

Boman Index

1.38

Hydrophobicity

-0.480

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor vessel

Homing or Targeting Homing

Target Tumor Epidermal squamous cell cancers

Receptors Biomarker MECA32 (Second endothelial marker, the cell-surface antigen)

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Progressive vascular changes in a transgenic mouse model of squamous cell carcinoma

Year 2003

Reference

Hoffman JA et al. Cancer Cell. 2003 Nov 4(5):383-91.

Patent US 2006/0002854A1

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVivo Model K14-HPV16 mice, FVB/b mice , C57B16 cells bearing mice,RIP1-Tag2 mice

Source Type Phage display library

Phage Display Library T7 phage /9-mer cyclic (CX7C) peptide library

Evidence 2 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell

Homing or Targeting Targeting

Target Tumor Lung cancer

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Compositions of a peptide targeting system for treating cancer

Year 2014

Reference

US 8680045 B2

Patent US 8680045 B2

Other

InVitro ExVivo SW900, H460, A549

InVivo Model Nude mice (20 g)

Source Type Phage display library

Conjugate Payload Cy5.5

Conjugate_Payload

Cy5.5

InVitro_ExVivo

SW900, H460, A549

InVivo_Model

K14-HPV16 mice, FVB/b mice , C57B16 cells bearing mice,RIP1-Tag2 mice Nude mice (20 g)

Phage_Display_Library

T7 phage /9-mer cyclic (CX7C) peptide library