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Peptide record

TPDB40686

mrIL-12vp [mouse recombinant interleukin (IL)-12 RGD 4C RGD-4C Anticancer Tumor-homing Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB40686
mrIL-12vp [mouse recombinant interleukin (IL)-12 RGD 4C RGD-4C
Anticancer Tumor-homing Peptides
Cancer-related peptides
Peptipedia StackTHP StackTHPred TumorHoPe2.0
standard
No
A 9-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.
Sequence
CDCRGDCFC
Physicochemical Analysis
C37H56N12O14S4
ANEQHILKMPSTWYV
C
1021.16
3.88
1
2
1
-1
1.19
0.100
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
250
24.48
4
Residue Composition
number
0
A
1
R
0
N
2
D
4
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 2 C: 4 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C37H56N12O14S4
1021.16
3.88
-1
1.19
0.100
RGD
Evidence Records 8 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Endothelial cells
Homing
Tumor neovasculature
Alpha-5 beta-3 integrins

Source & Reference

TumorHoPe2.0
TumorHoPe2
Enhancement of the antiangiogenic activity of interleukin-12 by peptide targeted delivery of the cytokine to alphavbeta3 integrin
2004
Dickerson EB et al. Mol Cancer Res. 2004 Dec 2(12):663-73.
US 2004/0131623A9

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
M21 human melanoma cells, Saos-2 osteosarcoma cells
Mice injected with NXS2 neuroblastoma cells
Synthetic
mrIl-12vp peptide
mrIL-12vp inhibits angiogenesis through IL-12-dependent
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Hepatic and pancreatic cancer
Integrins

Source & Reference

TumorHoPe2.0
TumorHoPe2
Potential tumor-targeting peptide vector of histidylated oligolysine conjugated to a tumor-homing RGD motif
2001
Aoki Y et al. Cancer Gene Ther. 2001 Oct 8(10):783-7.
US 2003/0152578 A1

Other

Human hepatoma cell lines ( PLC / PRF / 5 andHepG2 ) ,human pancreatic cancer cell lines ( Hs700T and MIAPaCa - 2 )
Phage display library
Evidence 3 Activity

Activity

Tumor-homing Peptides

Target

Endothelial cell
Homing
Human breast carcinoma
Integrin

Source & Reference

TumorHoPe2.0
TumorHoPe2
Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model
1999
Arap W et al. Science. 1998 Jan 16 279(5349):377-80.
US20030077818A1

Other

Mice bearing MDA-MB derived tumors
Phage display library
Doxorubicin
Evidence 4 Activity

Activity

Tumor-homing Peptides

Target

Homing
Malignant melanomas and breast carcinoma
Alpha -5 beta-1 integrin

Source & Reference

TumorHoPe2.0
TumorHoPe2
Alpha v integrins as receptors for tumor targeting by circulating ligands.
1997
Pasqualini R et al. Nat Biotechnol. 1997 Jun 15(6):542-6.

Other

MDA-MB-435 breast cancer cells, murine B16B15b melanoma,C8161 human melanoma
Female 2-month old BALB/ C mice
FliTrx bacterial peptide libra
Phage /RGD-4CLibrary
Evidence 5 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Lung cancer, Breast cancer, Liver cancer, Melanoma, stomach cancer, Pancreatic cancer, Colorectal cancer, Ovarian cancer, Renal cell carcinoma, Prostate cancer, Brain tumor

Source & Reference

TumorHoPe2.0
TumorHoPe2
Noxa-derived, cell death-inducing peptide eMTD
2022
US 11248024 B2
US 11248024 B2

Other

Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line
6-week-old BalB/C mice
Synthetic
necrosis-inducing peptide, Fluorescein (FAM)
Evidence 6 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
αvβ6

Source & Reference

TumorHoPe2.0
TumorHoPe2
Protease inhibitor:protease sensitive expression system, composition and methods for improving the therapeutic activity and specificity of proteins delivered by bacteria
2022
US 11219671 B1
US 11219671 B1

Other

Salmonella typhimurium
Phage display library
Ph.D-7 Phage Display
Evidence 7 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Breast cancer, Squamous cell carcinoma, Colon carcinoma
vimentin

Source & Reference

TumorHoPe2.0
TumorHoPe2
Carcinoma homing peptide (CHP), its analogs, and methods of using
2017
US 9657077 B2
US 9657077 B2

Other

SCCVII, CT26, 4T1, and B16F10 cell line
C57B1/6 mice, C3H mice, Nude mice, wtIL-12−/− mice, female Balb/c mice (all are six to eight weeks old)
Phage Display library
interleukin 12 (IL-12)
cyclic
Evidence 8 Activity

Activity

Tumor-homing Peptides

Target

Tumor vessel, Tumor cell, Endothelial cell
Targeting
Glioma
αvβ33, αvβ35 integrins

Source & Reference

TumorHoPe2.0
TumorHoPe2
Methods and compositions related to adenoassociated virus-phage particles
2017
US 9827327 B2
US 9827327 B2

Other

U87 human-derived glioblastoma cell, prostate DU145 carcinoma cells, Human umbilical vein endothelial cells (HUVEC), M21 human melanoma cells
BALB/c nude mice
Phage Display library
glycoproteins, FITC
Additional Detail Fields 4 fields
mrIl-12vp peptide Doxorubicin necrosis-inducing peptide, Fluorescein (FAM) interleukin 12 (IL-12) glycoproteins, FITC
M21 human melanoma cells, Saos-2 osteosarcoma cells Human hepatoma cell lines ( PLC / PRF / 5 andHepG2 ) ,human pancreatic cancer cell lines ( Hs700T and MIAPaCa - 2 ) MDA-MB-435 breast cancer cells, murine B16B15b melanoma,C8161 human melanoma Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line SCCVII, CT26, 4T1, and B16F10 cell line U87 human-derived glioblastoma cell, prostate DU145 carcinoma cells, Human umbilical vein endothelial cells (HUVEC), M21 human melanoma cells
Mice injected with NXS2 neuroblastoma cells Mice bearing MDA-MB derived tumors Female 2-month old BALB/ C mice 6-week-old BalB/C mice Salmonella typhimurium C57B1/6 mice, C3H mice, Nude mice, wtIL-12−/− mice, female Balb/c mice (all are six to eight weeks old) BALB/c nude mice
Phage /RGD-4CLibrary Ph.D-7 Phage Display