TPDB

3D PDB MODEL

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TPDB ID TPDB40665

Peptide_Name

G3-C9

Activity

Anticancer Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

Peptipedia StackTHP StackTHPred TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 16-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.

Sequence

AYTKCSRQWRTCMTTH

FASTA

>TPDB40665|Anticancer;Tumor-homing Peptides|length=16
AYTKCSRQWRTCMTTH

Formula C82H129N27O24S3

Absent Amino Acids NDEGILFPV

Common Amino Acids T

Mass 1973.27

PI 9.79

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +3

Boman Index 1.17

Hydrophobicity -1.044

Aliphatic Index 6.25

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 7115

Absorbance 280nm 360.57

Polar Residues 9

number

1

A

2

R

0

N

0

D

2

C

0

E

1

Q

0

G

1

H

0

I

0

L

1

K

1

M

0

F

0

P

1

S

4

T

1

W

1

Y

0

V

Amino Acid Distribution

A: 1 R: 2 N: 0 D: 0 C: 2 E: 0 Q: 1 G: 0 H: 1 I: 0 L: 0 K: 1 M: 1 F: 0 P: 0 S: 1 T: 4 W: 1 Y: 1 V: 0

Length

16

Formula

C82H129N27O24S3

Mass

1973.27

PI

9.79

Net Charge

+3

Boman Index

1.17

Hydrophobicity

-1.044

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Endothelial cell and tumor cell

Homing or Targeting Targeting & further studied

Target Tumor Tumor metastasis

Receptors Biomarker Galectin-3

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Peptides specific to the galectin-3 carbohydrate recognition domain inhibit metastasis-associated cancer cell adhesion

Year 2005

Reference

Zou J et al. Carcinogenesis. 2005 Feb 26(2):309-18.

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo

Human breast cancer cell lines BT549, express detectable levels of galectin-3, BT549trans,Human breast carcinoma cell line MDA-MB-435,Human prostate carcinoma cell line PC-3M,MDA-MB-435 human breast carcinoma cells on HBME-1 monolayers

Source Type Phage display library

Phage Display Library f88 phage/15mer peptide library and f88 phage/Cys6 mer peptide library

InVitro_ExVivo

Human breast cancer cell lines BT549, express detectable levels of galectin-3, BT549trans,Human breast carcinoma cell line MDA-MB-435,Human prostate carcinoma cell line PC-3M,MDA-MB-435 human breast carcinoma cells on HBME-1 monolayers

Phage_Display_Library

f88 phage/15mer peptide library and f88 phage/Cys6 mer peptide library