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Peptide record

TPDB40635

Clone PC5-11 Anticancer Tumor-homing Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB40635
Clone PC5-11
Anticancer Tumor-homing Peptides
Cancer-related peptides
Peptipedia StackTHP StackTHPred TumorHoPe2.0
standard
No
A 12-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.
Sequence
AQSTAFQKPLLM
Physicochemical Analysis
C60H99N15O17S1
RNDCEGHIWYV
AQL
1334.60
10.10
1
0
6
+1
0.05
0.158
81.67
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
4
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
2
Q
0
G
0
H
0
I
2
L
1
K
1
M
1
F
1
P
1
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 0 L: 2 K: 1 M: 1 F: 1 P: 1 S: 1 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C60H99N15O17S1
1334.60
10.10
+1
0.05
0.158
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor vessel
Homing (Phage display clone)
Lung cancer
Integrins, Alpha-5 beta-3 and Alpha-5 beta-5

Source & Reference

TumorHoPe2.0
TumorHoPe2
Peptide-mediated targeting to tumor blood vessels of lung cancer for drug delivery
2007
Lee TY et al. Cancer Res. 2007 Nov 15 67(22):10958-65.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
CL1-5 (lung cancer), H460 (lung cancer) ,PC-3 (prostate cancer),VEGF-stimulated HUVECs and human lung cancer vessels
SCID mice with lung cancer xenograft
Phage display library
M13 phage/random peptide library
Additional Detail Fields 3 fields
CL1-5 (lung cancer), H460 (lung cancer) ,PC-3 (prostate cancer),VEGF-stimulated HUVECs and human lung cancer vessels
SCID mice with lung cancer xenograft
M13 phage/random peptide library