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Peptide record

TPDB40623

G3-C12 Anticancer Tumor-homing Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB40623
G3-C12
Anticancer Tumor-homing Peptides
Cancer-related peptides
Peptipedia StackTHP StackTHPred TumorHoPe2.0
standard
No
A 16-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.
Sequence
ANTPCGPYTHDCPVKR
Physicochemical Analysis
C74H115N23O23S2
EQILMFSW
P
1758.99
8.28
3
1
3
+1
4.53
-0.969
24.38
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1615
91.81
6
Residue Composition
number
1
A
1
R
1
N
1
D
2
C
0
E
0
Q
1
G
1
H
0
I
0
L
1
K
0
M
0
F
3
P
0
S
2
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 1 C: 2 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 0 K: 1 M: 0 F: 0 P: 3 S: 0 T: 2 W: 0 Y: 1 V: 1
Chemical Descriptors
16
C74H115N23O23S2
1758.99
8.28
+1
4.53
-0.969
P-(C)-G-P-XXX-D(C)-P
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Endothelial cell and tumor cell
Targeting & further studied
Tumor metastasis
Galectin-3

Source & Reference

TumorHoPe2.0
TumorHoPe2
Peptides specific to the galectin-3 carbohydrate recognition domain inhibit metastasis-associated cancer cell adhesion
2005
Zou J et al. Carcinogenesis. 2005 Feb 26(2):309-18.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Human breast cancer cell lines BT549, express detectable levels of galectin-3, BT549trans,Human breast carcinoma cell line MDA-MB-435,Human prostate carcinoma cell line PC-3M,MDA-MB-435 human breast carcinoma cells on HBME-1 monolayers
Phage display library
f88 phage/15mer peptide library and f88 phage/Cys6 mer peptide library
Additional Detail Fields 2 fields
Human breast cancer cell lines BT549, express detectable levels of galectin-3, BT549trans,Human breast carcinoma cell line MDA-MB-435,Human prostate carcinoma cell line PC-3M,MDA-MB-435 human breast carcinoma cells on HBME-1 monolayers
f88 phage/15mer peptide library and f88 phage/Cys6 mer peptide library