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Peptide record

TPDB40615

Dermaseptin-SS1 Anticancer standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB40615
Dermaseptin-SS1
Anticancer
Cancer-related peptides
CancerPPD 2.0 dbACP
standard
No
A 22-aa standard natural anticancer peptide sequence curated from CancerPPD 2.0 and dbACP, with an available 3D structural model.
C-terminal: Amidation
Sequence
ALWKSILKNAGKAALNEINQIV-NH2
Physicochemical Analysis
C109H184N30O30
RDCHMFPTY
A
2394.84
10.32
3
1
12
+2
1.90
0.227
137.73
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
229.66
5
Residue Composition
number
4
A
0
R
3
N
0
D
0
C
1
E
1
Q
1
G
0
H
3
I
3
L
3
K
0
M
0
F
0
P
1
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 0 N: 3 D: 0 C: 0 E: 1 Q: 1 G: 1 H: 0 I: 3 L: 3 K: 3 M: 0 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
22
C109H184N30O30
2394.84
10.32
+2
1.90
0.227
Amidation
L
Linear
Free
Antimicrobial and Anticancer
Brown-belly leaf frog, Phyllomedusa Tarsius
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
IC50 = 7.7 µM
Anticancer
7.7 µM

Target

Lung Cancer
H-838
Lung

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2023

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

IC50
IC50 = 1.3 µM
Anticancer
1.3 µM

Target

Lung Cancer
H-460
Lung

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2023