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Peptide record

TPDB40586

NL2 Anticancer Tumor-homing Peptides standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB40586
NL2
Anticancer Tumor-homing Peptides
Cancer-related peptides
Peptipedia StackTHP StackTHPred TumorHoPe2.0
standard
No
A 22-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.
Sequence
AEGEFIHNRYNRFFYWYGDPAK
Physicochemical Analysis
C132H174N34O34
CQLMSTV
FY
2781.04
7.66
4
3
10
+0
1.44
-1.105
26.82
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
9970
358.50
5
Residue Composition
number
2
A
2
R
2
N
1
D
0
C
2
E
0
Q
2
G
1
H
1
I
0
L
1
K
0
M
3
F
1
P
0
S
0
T
1
W
3
Y
0
V
Amino Acid Distribution
A: 2 R: 2 N: 2 D: 1 C: 0 E: 2 Q: 0 G: 2 H: 1 I: 1 L: 0 K: 1 M: 0 F: 3 P: 1 S: 0 T: 0 W: 1 Y: 3 V: 0
Chemical Descriptors
22
C132H174N34O34
2781.04
7.66
+0
1.44
-1.105
Evidence Records 2 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Breast cancer
HER2(Human epidermal growth factor receptor 2)

Source & Reference

TumorHoPe2.0
TumorHoPe2
Targeted gene transduction of mammalian cells expressing the HER2/neu receptor by filamentous phage
2001
Urbanelli L et al. J Mol Biol. 2001 Nov 9 313(5):965-76.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Human breast carcinoma SK-Br-3, human ovarian carcinoma SKOV3, human melanoma MeWo and mouse fibroblast NIH3T3 cells
Phage display library
T7 phage/12 mer peptide library
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
HER2-positive Breast cancer
HER2

Source & Reference

TumorHoPe2.0
TumorHoPe2
Molecular imprinting of miR-559 on a peptide-immobilized poly L-DOPA/silica core-shell and in vitro investigating its effects on HER2-positive breast cancer cells
2023
Hadi Mohammadzade et al. Drug Deliv Transl Res. 2023 Oct 13(10):2487-2502.

Other

The SKBR3 cell line (ATCC HTB-30), MDA-MB-231 (ATCC HTB-26)
Synthetic
miR-559, Poly L-DOPA/silica nanoparticles (NC-NL2)
Additional Detail Fields 3 fields
miR-559, Poly L-DOPA/silica nanoparticles (NC-NL2)
Human breast carcinoma SK-Br-3, human ovarian carcinoma SKOV3, human melanoma MeWo and mouse fibroblast NIH3T3 cells The SKBR3 cell line (ATCC HTB-30), MDA-MB-231 (ATCC HTB-26)
T7 phage/12 mer peptide library