TPDB

3D PDB MODEL

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TPDB ID TPDB40581

Peptide_Name

Chickpea

Activity

Anticancer

Activity_category_statistics

Cancer-related peptides

Database_Source

CancerPPD 2.0 dbACP

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural anticancer peptide sequence curated from CancerPPD 2.0 and dbACP, with an available 3D structural model.

Sequence

ADLPGLK

FASTA

>TPDB40581|Anticancer|length=7
ADLPGLK

Formula C32H56N8O10

Absent Amino Acids RNCEQHIMFSTWYV

Common Amino Acids L

Mass 712.84

PI 6.75

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 3

Net Charge -0

Boman Index 1.39

Hydrophobicity -0.000

Aliphatic Index 125.71

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

1

A

0

R

0

N

1

D

0

C

0

E

0

Q

1

G

0

H

0

I

2

L

1

K

0

M

0

F

1

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 2 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

7

Formula

C32H56N8O10

Mass

712.84

PI

6.75

Net Charge

-0

Boman Index

1.39

Hydrophobicity

-0.000

C_terminal_Modification

Free

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Anticancer

Origin

Cicer arietinum L.

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 133.4 ± 0.70µM

Detail Source Activity Anticancer

Activity Measurement 133.4

Target

Cancer Type Ovarian Cancer

Cell Line PA-1

Tissue Affected Ovary

Assay & Model

Assay Sulforhodamine B assay

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2021

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 101.5 ± 1.83 µM

Detail Source Activity Anticancer

Activity Measurement 101.5

Target

Cancer Type Endometrial Cancer

Cell Line Ishikawa

Tissue Affected Endometrium

Assay & Model

Assay Sulforhodamine B assay

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2021

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 126.4 ± 1.98 µM

Detail Source Activity Anticancer

Activity Measurement 126.4

Target

Cancer Type Lung Cancer

Cell Line A-549

Tissue Affected Lung

Assay & Model

Assay Sulforhodamine B assay

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2021

Evidence 4 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 113.7 ± 0.99 µM

Detail Source Activity Anticancer

Activity Measurement 113.7

Target

Cancer Type Liver Cancer

Cell Line HepG-2

Tissue Affected Liver

Assay & Model

Assay Sulforhodamine B assay

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2021

Evidence 5 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 107.2 ± 1.62µM

Detail Source Activity Anticancer

Activity Measurement 107.2

Target

Cancer Type Breast Cancer

Cell Line MDA-MB-231

Tissue Affected Breast

Assay & Model

Assay Sulforhodamine B assay

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2021

Evidence 6 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 110.3 ± 2.97µM

Detail Source Activity Anticancer

Activity Measurement 110.3

Target

Cancer Type Breast Cancer

Cell Line MCF-7

Tissue Affected Breast

Assay & Model

Assay Sulforhodamine B assay

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2021