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Peptide record

TPDB40568

IDP-NS10 Anticancer standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB40568
IDP-NS10
Anticancer
Cancer-related peptides
CancerPPD 2.0
standard
No
A 16-aa standard natural anticancer peptide sequence curated from CancerPPD 2.0, with an available 3D structural model.
Chemical: -(CH2)6-CH=CH-(CH2)3 Chemical: a biradical linker links L(3) and A(10)
Sequence
AALVVILKKATEYVHS
Physicochemical Analysis
C81H136N20O22
RNDCQGMFPW
AV
1742.09
9.65
3
1
10
+1
2.56
0.800
146.25
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1490
85.53
3
Residue Composition
number
3
A
0
R
0
N
0
D
0
C
1
E
0
Q
0
G
1
H
1
I
2
L
2
K
0
M
0
F
0
P
1
S
1
T
0
W
1
Y
3
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 1 I: 1 L: 2 K: 2 M: 0 F: 0 P: 0 S: 1 T: 1 W: 0 Y: 1 V: 3
Chemical Descriptors
16
C81H136N20O22
1742.09
9.65
+1
2.56
0.800
Free
-(CH2)6-CH=CH-(CH2)3 a biradical linker links L(3) and A(10)
L
Linear
Free
Anticancer
Synthetic
Evidence Records 8 records
Evidence 1 Activity

Activity

EC50
EC50 ~ 7 µM
Anticancer
7 µM

Target

Glioblastoma
RG1
Brain

Assay & Model

AlamarBlue assay
72-96 h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019
WO 2019/025432 A1 US011352395B2

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

EC50
EC50 ~ 7.5 µM
Anticancer
7.5 µM

Target

Glioblastoma
GMB-27
Brain

Assay & Model

AlamarBlue assay
72-96 h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019
WO 2019/025432 Al US20200157150A1
Evidence 3 Activity

Activity

EC50
EC50 ~ 10 µM
Anticancer
10 µM

Target

Glioblastoma
12015
Brain

Assay & Model

AlamarBlue assay
72-96 h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019
WO 2019/025432 Al
Evidence 4 Activity

Activity

EC50
EC50 ~ 4 µM
Anticancer
4 µM

Target

Glioblastoma
12089
Brain

Assay & Model

AlamarBlue assay
72-96 h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019
WO 2019/025432 Al
Evidence 5 Activity

Activity

EC50
EC50 ~ 5 µM
Anticancer
5 µM

Target

Glioblastoma
RG6
Brain

Assay & Model

AlamarBlue assay
72-96 h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019
WO 2019/025432 Al
Evidence 6 Activity

Activity

EC50
EC50 ~ 5 µM
Anticancer
5 µM

Target

Glioblastoma
RG4
Brain

Assay & Model

AlamarBlue assay
72-96 h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019
WO 2019/025432 Al
Evidence 7 Activity

Activity

EC50
EC50 ~ 7 µM
Anticancer
7 µM

Target

Glioblastoma
RG5
Brain

Assay & Model

AlamarBlue assay
72-96 h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019
WO 2019/025432 Al
Evidence 8 Activity

Activity

EC50
EC50 ~ 50 µM
Anticancer
50 µM

Target

Glioblastoma
12053
Brain

Assay & Model

AlamarBlue assay
72-96 h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019
WO 2019/025432 Al