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Peptide record

TPDB40550

Neurotoxin Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB40550
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 14-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
DMCCHPACMNHFNC
Physicochemical Analysis
C63H92N20O19S6
REQGILKSTWYV
C
1625.91
5.99
2
1
4
-1
1.72
-0.007
7.14
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
250
15.38
6
Residue Composition
number
1
A
0
R
2
N
1
D
4
C
0
E
0
Q
0
G
2
H
0
I
0
L
0
K
2
M
1
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 2 D: 1 C: 4 E: 0 Q: 0 G: 0 H: 2 I: 0 L: 0 K: 0 M: 2 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
14
C63H92N20O19S6
1625.91
5.99
-1
1.72
-0.007
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin inhibits muscle nAChRs with moderate potency (IC(50)=11 uM on alpha-1-beta-1-delta-epsilon/CHRNA1-CHRNB1-CHRND-CHRNE (adult), and IC(50)=13 uM on alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND (fetal)). {ECO:0000269|PubMed:31527432}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus milneedwardsi (Glory of India cone snail)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin inhibits muscle nAChRs with moderate potency (IC(50)=11 uM on alpha-1-beta-1-delta-epsilon/CHRNA1-CHRNB1-CHRND-CHRNE (adult), and IC(50)=13 uM on alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND (fetal))..
Alpha-conotoxin MilIA
cone snail
Conotoxin A superfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:31527432}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin MilIA
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:31527432}.
cone snail