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Peptide record

TPDB40469

Neurotoxin Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB40469
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
GGCRYFLGGCSEHSDCCEHLRCKMGLNYCAWDGTF
Physicochemical Analysis
C165H240N48O50S7
QIPV
CG
3920.43
6.02
5
4
10
-1
2.40
-0.266
36.29
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
8855
225.87
12
Residue Composition
number
1
A
2
R
1
N
2
D
6
C
2
E
0
Q
6
G
2
H
0
I
3
L
1
K
1
M
2
F
0
P
2
S
1
T
1
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 1 D: 2 C: 6 E: 2 Q: 0 G: 6 H: 2 I: 0 L: 3 K: 1 M: 1 F: 2 P: 0 S: 2 T: 1 W: 1 Y: 2 V: 0
Chemical Descriptors
35
C165H240N48O50S7
3920.43
6.02
-1
2.40
-0.266
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Gating-modifier toxin with weak activity on Nav1.7/SCN9A and Nav1.8/SCN10A (PubMed:32092883). Inhibits Nav1.7/SCN9A peak current (IC(50)=334 nM) and shifts the voltage dependence of activation to more depolarised membrane potentials (PubMed:32092883). Shows 21% peak current inhibition (at 10 uM) on Nav1.8/SCN10A sodium channels (PubMed:32092883). {ECO:0000269|PubMed:32092883}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Poecilotheria metallica (Metallic blue ornamental tree spider)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Gating-modifier toxin with weak activity on Nav1.7/SCN9A and Nav1.8/SCN10A (PubMed:32092883). Inhibits Nav1.7/SCN9A peak current (IC(50)=334 nM) and shifts the voltage dependence of activation to more depolarised membrane potentials (PubMed:32092883).
Mu-theraphotoxin-Pm1a (Mu-TRTX-Pm1a)
spider
Neurotoxin 10 (Hwtx-1) family, 62 (Vatx) subfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:32092883}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 62 (Vatx) subfamily
Mu-theraphotoxin-Pm1a (Mu-TRTX-Pm1a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:32092883}.
spider