Evidence 1
Activity
Activity
Neurotoxin
FUNCTION: Gating-modifier toxin that targets voltage-gated sodium channels with a preferential activity on Nav1.7/SCN9A. On Nav1.7/SCN9A, the toxin acts by shifting the voltage-dependence of activation to more depolarized potentials, whereas it does not cause significant effect on the voltage-dependence of activation on other sodium channels. Minor effects are observed on the voltage-dependence of steady-state fast inactivation for all sodium channels tested (Nav1.1/SCN1A-Nav1.8/SCN10A). By testing the toxin on channel chimera, it has been shown to interact with the S3-S4 linkers in DII and DIV domains of Nav1.7/SCN9A. In vivo, the toxin dose-dependently reduces OD1-induced spontaneous pain behaviors. {ECO:0000250|UniProtKB:P0DM12}.
Target
voltage-gated sodium channel (Nav)
Source & Reference
NA
UniProtKB/Swiss-Prot Tox-Prot
Other
Pamphobeteus nigricolor (Giant blue bloom tarantula)
Neurotoxin
Ion channel impairing toxin
Voltage-gated sodium channel impairing toxin
Gating-modifier toxin that targets voltage-gated sodium channels with a preferential activity on Nav1.7/SCN9A. On Nav1.7/SCN9A, the toxin acts by shifting the voltage-dependence of activation to more depolarized potentials, whereas it does not cause significant effect on the voltage-dependence of activation on other sodium channels.
Mu-theraphotoxin-Pn3b (Mu-TRTX-Pn3b)
spider
Neurotoxin 10 (Hwtx-1) family, 28 (Jztx-11) subfamily
Evidence at protein level
Direct protein sequencing
Disulfide bond
Ion channel impairing toxin
Knottin
Neurotoxin
Secreted
Toxin
Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:28106092}.