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Peptide record

TPDB40466

Neurotoxin Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB40466
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
DLVQFGQMILKVAGRSLPKSYGAYGCYCGWGGRGK
Physicochemical Analysis
C169H261N47O45S3
NEHT
G
3767.40
9.78
5
1
14
+4
-0.93
-0.137
66.86
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
10095
267.96
9
Residue Composition
number
2
A
2
R
0
N
1
D
2
C
0
E
2
Q
8
G
0
H
1
I
3
L
3
K
1
M
1
F
1
P
2
S
0
T
1
W
3
Y
2
V
Amino Acid Distribution
A: 2 R: 2 N: 0 D: 1 C: 2 E: 0 Q: 2 G: 8 H: 0 I: 1 L: 3 K: 3 M: 1 F: 1 P: 1 S: 2 T: 0 W: 1 Y: 3 V: 2
Chemical Descriptors
35
C169H261N47O45S3
3767.40
9.78
+4
-0.93
-0.137
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Snake venom phospholipase A2 (PLA2) that shows presynaptic neurotoxicity. 10 ug/ml of this protein produce complete neuromuscular blockade up to 80 minutes, without inhibiting the responses to acetylcholine (ACh) and potassium chloride (KCl). In addition, it produces a calcium-dependent blockade of acetylcholine release and causes appearance of giant miniature end-plate potentials. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. {ECO:0000269|Ref.1}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Bothrops pauloensis (Neuwied's lancehead) (Bothrops neuwiedi pauloensis)
Neurotoxin Presynaptic neurotoxin
Snake venom phospholipase A2 (PLA2) that shows presynaptic neurotoxicity. 10 ug/ml of this protein produce complete neuromuscular blockade up to 80 minutes, without inhibiting the responses to acetylcholine (ACh) and potassium chloride (KCl).
Phospholipase A2 neuwieditoxin-1 (NeuTX-1) (PLA2) (EC 3.1.1.4) (Neuwieditoxin-I) (NeuTX-I) (Phosphatidylcholine 2-acylhydrolase)
snake
Phospholipase A2 family, Group II subfamily, D49 sub-subfamily
Evidence at protein level
Calcium Direct protein sequencing Disulfide bond Hydrolase Lipid degradation Lipid metabolism Metal-binding Neurotoxin Presynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Calcium Direct protein sequencing Disulfide bond Hydrolase Lipid degradation Lipid metabolism Metal-binding Neurotoxin Presynaptic neurotoxin Secreted Toxin
Neurotoxin Presynaptic neurotoxin
Evidence at protein level
Phospholipase A2 family, Group II subfamily, D49 sub-subfamily
Phospholipase A2 neuwieditoxin-1 (NeuTX-1) (PLA2) (EC 3.1.1.4) (Neuwieditoxin-I) (NeuTX-I) (Phosphatidylcholine 2-acylhydrolase)
TISSUE SPECIFICITY: Expressed by the venom gland.
snake