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Peptide record

TPDB40461

Neurotoxin Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB40461
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
ACLGFGKSCNPSNDQCCKSSSLACSTKHKWCKYEL
Physicochemical Analysis
C160H252N46O51S6
RIMV
CS
3828.40
8.31
6
2
8
+3
4.59
-0.500
39.14
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
7365
192.38
17
Residue Composition
number
2
A
0
R
2
N
1
D
6
C
1
E
1
Q
2
G
1
H
0
I
3
L
5
K
0
M
1
F
1
P
6
S
1
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 2 D: 1 C: 6 E: 1 Q: 1 G: 2 H: 1 I: 0 L: 3 K: 5 M: 0 F: 1 P: 1 S: 6 T: 1 W: 1 Y: 1 V: 0
Chemical Descriptors
35
C160H252N46O51S6
3828.40
8.31
+3
4.59
-0.500
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Gating-modifier toxin that reversibly and voltage-independently inhibits human Nav1.1/SCN1A and Nav1.7/SCN9A (IC(50)=111 nM) (PubMed:25754331). It also shows moderate inhibition on Nav1.2/SCN2A (1 uM inhibits current by 55%), Nav1.6/SCN8A (31%), Nav1.3/SCN5A (27%) and Nav1.4/SCN4A (23%) (PubMed:25754331). This toxin inhibits Nav1.7/SCN9A by interacting with the S3b-S4 paddle motif in channel domain II (PubMed:25754331). {ECO:0000269|PubMed:25754331}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Cyriopagopus doriae (Tarantula spider) (Haplopelma doriae)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Gating-modifier toxin that reversibly and voltage-independently inhibits human Nav1.1/SCN1A and Nav1.7/SCN9A (IC(50)=111 nM) (PubMed:25754331). It also shows moderate inhibition on Nav1.2/SCN2A (1 uM inhibits current by 55%), Nav1.6/SCN8A (31%), Nav1.3/SCN5A (27%) and Nav1.4/SCN4A (23%) (PubMed:25754331).
Mu-theraphotoxin-Hd1a (Mu-TRTX-Hd1a)
spider
Neurotoxin 10 (Hwtx-1) family, 22 (Htx-4) subfamily
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:25754331}.
Additional Detail Fields 7 fields
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 22 (Htx-4) subfamily
Mu-theraphotoxin-Hd1a (Mu-TRTX-Hd1a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:25754331}.
spider