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Peptide record

TPDB40453

Neurotoxin Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB40453
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 12-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
RIRKPIFAFPRF
Physicochemical Analysis
C76H118N22O13
NDCEQGHLMSTWYV
RF
1547.91
12.71
4
0
6
+4
0.14
-0.117
73.33
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
1
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
0
L
1
K
0
M
3
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 0 K: 1 M: 0 F: 3 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C76H118N22O13
1547.91
12.71
+4
0.14
-0.117
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Conorfamide As2a: this amidated form is active on both ASIC channels and nicotinic acetylcholine receptors (nAChRs) (PubMed:31028742). Potentiates ASIC1a (EC(50)=10.9 uM) (PubMed:31028742). Inhibits desensitization of ASIC1a and to a lesser degree ASIC3 currents, resulting in a sustained opening of channels in the presence of low pH (PubMed:31028742). Inhibits with a slow reversibility human alpha-7/CHRNA7 nAChRs (IC(50)=689-3867 nM) and with a rapid reversibility human alpha-1-beta-1-delta-epsilon (CHRNA1-CHRNB1-CHRND-CHRNE) nAChRs (IC(50)=208 nM) (PubMed:31028742). {ECO:0000269|PubMed:31028742}. FUNCTION: Conorfamide As2b: this non-amidated form is only weakly active on both ASIC channels and nicotinic acetylcholine receptors (nAChRs) (PubMed:31028742). Shows a very weak inhibition of peak current of rat ASIC1a and ASIC3 (PubMed:31028742). No inhibition or very weak desensitization of both rat ASIC1a and ASIC3 are observed (PubMed:31028742). Reversibly inhibits both human alpha-7/CHRNA7 nAChRs (IC(50)=2971-7036 nM) and human alpha-1-beta-1-delta-epsilon (CHRNA1-CHRNB1-CHRND-CHRNE) nAChRs (IC(50)=707 nM) (PubMed:31028742). {ECO:0000269|PubMed:31028742}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor voltage-gated sodium channel (Nav) proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus cancellatus (Cancellate cone) (Conus austini)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin Proton-gated sodium channel impairing toxin
Conorfamide As2a: this amidated form is active on both ASIC channels and nicotinic acetylcholine receptors (nAChRs) (PubMed:31028742). Potentiates ASIC1a (EC(50)=10.9 uM) (PubMed:31028742).
Conorfamide-As2 (Conorfamide-As2a) (CNF-As2a) (Cono-RFamide-As2a) (Conorfamide-As2b) (CNF-As2b) (Cono-RFamide-As2b)
cone snail
FARP (FMRFamide related peptide) family
Evidence at protein level
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Proton-gated sodium channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:31028742}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Proton-gated sodium channel impairing toxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin Proton-gated sodium channel impairing toxin
Evidence at protein level
FARP (FMRFamide related peptide) family
Conorfamide-As2 (Conorfamide-As2a) (CNF-As2a) (Cono-RFamide-As2a) (Conorfamide-As2b) (CNF-As2b) (Cono-RFamide-As2b)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:31028742}.
cone snail