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Peptide record

TPDB40431

Neurotoxin Toxicity standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB40431
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 34-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
ECKYLWGTCSKDEDCCAHLGCNRKHDWCGWDYTF
Physicochemical Analysis
C176H246N48O53S6
QIMPV
C
4074.54
5.27
6
6
9
-2
4.23
-0.841
25.88
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
19855
487.29
12
Residue Composition
number
1
A
1
R
1
N
4
D
6
C
2
E
0
Q
3
G
2
H
0
I
2
L
3
K
0
M
1
F
0
P
1
S
2
T
3
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 4 C: 6 E: 2 Q: 0 G: 3 H: 2 I: 0 L: 2 K: 3 M: 0 F: 1 P: 0 S: 1 T: 2 W: 3 Y: 2 V: 0
Chemical Descriptors
34
C176H246N48O53S6
4074.54
5.27
-2
4.23
-0.841
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Ion channel impairing toxin that inhibits voltage-gated sodium channels. The recombinantly expressed toxin shows a weak activity against Nav1.7/SCN9A (25% inhibition at 10 uM), and shifts the voltage dependence of channel activation to more depolarized potentials. {ECO:0000269|PubMed:32511987}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Phormingochilus everetti (Malaysian purple earth tiger tarantula)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Ion channel impairing toxin that inhibits voltage-gated sodium channels. The recombinantly expressed toxin shows a weak activity against Nav1.7/SCN9A (25% inhibition at 10 uM), and shifts the voltage dependence of channel activation to more depolarized potentials..
Beta/mu-theraphotoxin-Pe1a (Beta/mu-TRTX-Pe1a)
spider
Neurotoxin 10 (Hwtx-1) family, 54 (ProTx-1) subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:32511987}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 54 (ProTx-1) subfamily
Beta/mu-theraphotoxin-Pe1a (Beta/mu-TRTX-Pe1a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:32511987}.
spider