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Peptide record

TPDB40428

Neurotoxin Toxicity standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB40428
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 34-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
GASCDCHPFKGTYWFGTSNCPSGHGYRKKCDSFF
Physicochemical Analysis
C168H232N46O48S4
EQILMV
G
3792.21
8.30
6
2
8
+2
0.95
-0.688
2.94
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
8730
230.21
13
Residue Composition
number
1
A
1
R
1
N
2
D
4
C
0
E
0
Q
5
G
2
H
0
I
0
L
3
K
0
M
4
F
2
P
4
S
2
T
1
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 2 C: 4 E: 0 Q: 0 G: 5 H: 2 I: 0 L: 0 K: 3 M: 0 F: 4 P: 2 S: 4 T: 2 W: 1 Y: 2 V: 0
Chemical Descriptors
34
C168H232N46O48S4
3792.21
8.30
+2
0.95
-0.688
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Peptide with both antimicrobial and neurotoxin activities. Cationic AMP with antimicrobial activity against both Gram-positive bacteria (B.subtilis) and Gram-negative bacteria (E.coli and S.enterica). Shows no significant antimicrobial activity against bacteria S.aureus and P.aeruginosa, as well as the fungus C.albicans. In vivo, induces reversible paralytic activity towards the shrimp P.paucidens. May act by impairing sodium or potassium channels in the prey. {ECO:0000250|UniProtKB:A0A1X9QHL1}.

Target

voltage-gated potassium channel (Kv) proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Urticina crassicornis (Mottled anemone) (Tealia crassicornis)
Neurotoxin Ion channel impairing toxin
Peptide with both antimicrobial and neurotoxin activities. Cationic AMP with antimicrobial activity against both Gram-positive bacteria (B.subtilis) and Gram-negative bacteria (E.coli and S.enterica).
Crassicorin-II (BDS-like antimicrobial peptide) (BDS-like AMP)
sea anemone
Sea anemone type 3 (BDS) potassium channel toxin family
Evidence at protein level
Antibiotic Antimicrobial Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Immunity Innate immunity Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Highly expressed by the mesenteries. Moderately expressed by the pharynx. Weakly expressed by the gonad and pedal disk. No expression in tentacle. {ECO:0000250|UniProtKB:A0A1X9QHL1}.
Additional Detail Fields 7 fields
Antibiotic Antimicrobial Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Immunity Innate immunity Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin
Neurotoxin Ion channel impairing toxin
Evidence at protein level
Sea anemone type 3 (BDS) potassium channel toxin family
Crassicorin-II (BDS-like antimicrobial peptide) (BDS-like AMP)
TISSUE SPECIFICITY: Highly expressed by the mesenteries. Moderately expressed by the pharynx. Weakly expressed by the gonad and pedal disk. No expression in tentacle. {ECO:0000250|UniProtKB:A0A1X9QHL1}.
sea anemone