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Peptide record

TPDB40427

Neurotoxin Toxicity standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB40427
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 34-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
ECRYWLGGCSKTGDCCEHLSCSPKWHWCVWDGTF
Physicochemical Analysis
C175H243N47O49S6
ANQIM
C
3981.50
6.02
5
4
9
-1
0.41
-0.441
31.47
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
23865
599.40
12
Residue Composition
number
0
A
1
R
0
N
2
D
6
C
2
E
0
Q
4
G
2
H
0
I
2
L
2
K
0
M
1
F
1
P
3
S
2
T
4
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 2 C: 6 E: 2 Q: 0 G: 4 H: 2 I: 0 L: 2 K: 2 M: 0 F: 1 P: 1 S: 3 T: 2 W: 4 Y: 1 V: 1
Chemical Descriptors
34
C175H243N47O49S6
3981.50
6.02
-1
0.41
-0.441
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Ion channel impairing toxin that inhibits several voltage-gated sodium channels. It acts by inhibiting the inward component of the sodium current and by shifting the voltage dependence of channel activation to more depolarized potentials (PubMed:32511987). Its most potent activity is on Nav1.7/SCN9A (IC(50)=167 nM), followed by Nav1.6/SCN8A (IC(50)=696 nM), and Nav1.2/SCN2A (IC(50)=3.54 uM) (PubMed:32511987). {ECO:0000269|PubMed:32511987}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Phormingochilus everetti (Malaysian purple earth tiger tarantula)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Ion channel impairing toxin that inhibits several voltage-gated sodium channels. It acts by inhibiting the inward component of the sodium current and by shifting the voltage dependence of channel activation to more depolarized potentials (PubMed:32511987).
Beta/mu-theraphotoxin-Pe1b (Beta/mu-TRTX-Pe1b)
spider
Neurotoxin 10 (Hwtx-1) family, 54 (ProTx-1) subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:32511987}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 54 (ProTx-1) subfamily
Beta/mu-theraphotoxin-Pe1b (Beta/mu-TRTX-Pe1b)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:32511987}.
spider