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Peptide record

TPDB40425

Neurotoxin Toxicity standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB40425
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 34-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
ECRWFLGGCSGGQTCCEHLVCHRKHQWCVWDWSF
Physicochemical Analysis
C180H251N53O46S6
ANIMPY
C
4085.66
7.01
6
3
10
+0
0.28
-0.321
40.00
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
22375
547.65
11
Residue Composition
number
0
A
2
R
0
N
1
D
6
C
2
E
2
Q
4
G
3
H
0
I
2
L
1
K
0
M
2
F
0
P
2
S
1
T
4
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 1 C: 6 E: 2 Q: 2 G: 4 H: 3 I: 0 L: 2 K: 1 M: 0 F: 2 P: 0 S: 2 T: 1 W: 4 Y: 0 V: 2
Chemical Descriptors
34
C180H251N53O46S6
4085.66
7.01
+0
0.28
-0.321
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits sodium channel Nav1.7/SCN9A with high potency (IC(50)=117 nM) and Nav1.2/SCN2A, Nav1.3/SCN3A, Nav1.6/SCN8A and Nav1.5/SCN5 with weaker potency. Also inhibits voltage-gated calcium channel Cav3.1/CACNA1G, Cav3.2/CACNA1H and Cav3.3/CACNA1I. {ECO:0000269|PubMed:28542706}.

Target

voltage-gated sodium channel (Nav) voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Davus fasciatus (Costa Rican tiger rump) (Cyclosternum fasciatus)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
Inhibits sodium channel Nav1.7/SCN9A with high potency (IC(50)=117 nM) and Nav1.2/SCN2A, Nav1.3/SCN3A, Nav1.6/SCN8A and Nav1.5/SCN5 with weaker potency. Also inhibits voltage-gated calcium channel Cav3.1/CACNA1G, Cav3.2/CACNA1H and Cav3.3/CACNA1I..
Mu-theraphotoxin-Df1a (Mu-TRTX-Df1a)
spider
Neurotoxin 10 (Hwtx-1) family, 54 (ProTx-1) subfamily
Evidence at protein level
Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:28542706}.
Additional Detail Fields 7 fields
Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 54 (ProTx-1) subfamily
Mu-theraphotoxin-Df1a (Mu-TRTX-Df1a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:28542706}.
spider