Back to search

Peptide record

TPDB40387

Antiviral Neurotoxin Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB40387
Antiviral Neurotoxin Toxicity
Anti-infective peptides Toxicity and safety peptides
AVPpred-BWR NTxPred2 ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Antiviral, Neurotoxin, and Toxicity) peptide sequence curated from AVPpred-BWR, NTxPred2, and ToxinPred 3.0, with an available 3D structural model.
Sequence
ECKGFGKSCVPGKNECCSGLTCSNKHKWCKVLL
Physicochemical Analysis
C152H248N44O44S6
ARDQIMY
CK
3588.27
8.59
7
2
7
+4
6.84
-0.309
53.03
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
5875
163.73
12
Residue Composition
number
0
A
0
R
2
N
0
D
6
C
2
E
0
Q
4
G
1
H
0
I
3
L
6
K
0
M
1
F
1
P
3
S
1
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 0 N: 2 D: 0 C: 6 E: 2 Q: 0 G: 4 H: 1 I: 0 L: 3 K: 6 M: 0 F: 1 P: 1 S: 3 T: 1 W: 1 Y: 0 V: 2
Chemical Descriptors
33
C152H248N44O44S6
3588.27
8.59
+4
6.84
-0.309
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potently and reversibly inhibits some human voltage-gated sodium channels (Nav1.1/SCN1A (IC(50)=72.0 nM), Nav1.2/SCN2A (IC(50)=75.5 nM), Nav1.6/SCN8A (IC(50)=115.0 nM), Nav1.7/SCN9A (IC(50)=52.7-129.5 nM), Nav1.3/SCN3A (IC(50)=306.6 nM)) (PubMed:30784059). The hNav1.7/SCN9A channel inhibition occurs without any change in steady-state inactivation- and conductance-voltage relationships (PubMed:30784059). On adult mouse DRG neurons, this toxin is approximately 1000-fold more efficient to inhibit tetrodotoxin (TTX)-sensitive than TTX-resistant sodium currents (PubMed:30784059). In vivo, this toxin exhibits analgesic effects in mice pain models (PubMed:30784059). {ECO:0000269|PubMed:30784059}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Omothymus schioedtei (Malaysian earth tiger tarantula) (Cyriopagopus schioedtei)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Potently and reversibly inhibits some human voltage-gated sodium channels (Nav1.1/SCN1A (IC(50)=72.0 nM), Nav1.2/SCN2A (IC(50)=75.5 nM), Nav1.6/SCN8A (IC(50)=115.0 nM), Nav1.7/SCN9A (IC(50)=52.7-129.5 nM), Nav1.3/SCN3A (IC(50)=306.6 nM)) (PubMed:30784059). The hNav1.7/SCN9A channel inhibition occurs without any change in steady-state inactivation- and conductance-voltage relationships (PubMed:30784059).
Mu-theraphotoxin-Os1a (Mu-TRTX-Os1a) (Cyriotoxin-1a) (CyrTx-1a) (Mu-theraphotoxin-Cs1a)
spider
Neurotoxin 10 (Hwtx-1) family, 14 (Hntx-1) subfamily
Evidence at protein level
3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:30784059}.
Additional Detail Fields 7 fields
3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 14 (Hntx-1) subfamily
Mu-theraphotoxin-Os1a (Mu-TRTX-Os1a) (Cyriotoxin-1a) (CyrTx-1a) (Mu-theraphotoxin-Cs1a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:30784059}.
spider