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Peptide record

TPDB40384

Neurotoxin Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB40384
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
DCLGFMKPCDINNDKCCSSYVCGRNNHWCKFHL
Physicochemical Analysis
C163H244N48O47S7
AEQT
C
3852.44
7.65
6
3
9
+1
3.72
-0.439
44.24
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
7365
191.18
13
Residue Composition
number
0
A
1
R
4
N
3
D
6
C
0
E
0
Q
2
G
2
H
1
I
2
L
3
K
1
M
2
F
1
P
2
S
0
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 4 D: 3 C: 6 E: 0 Q: 0 G: 2 H: 2 I: 1 L: 2 K: 3 M: 1 F: 2 P: 1 S: 2 T: 0 W: 1 Y: 1 V: 1
Chemical Descriptors
33
C163H244N48O47S7
3852.44
7.65
+1
3.72
-0.439
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Gating-modifier toxin that inhibits both sodium (Nav) and calcium (Cav3) channels by inducing hyperpolarizing shift in voltage-dependence of activation and steady state inactivation. Inhibits Nav1.1/SCN1A, Nav1.2/SCN2A, Nav1.6/SCN6A, Nav1.7/SCN9A and Cav3.1/CACNA1G sodium and calcium channels at nanomolar concentrations (IC(50)=169-621 nM). Surprisingly, selectively slows fast inactivation of Nav1.3/SCN3A. Also shows moderate inhibition of Nav1.3/SCN3A sodium channels (IC(50)=1216 nM). {ECO:0000269|PubMed:32826759}.

Target

voltage-gated sodium channel (Nav) voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Theraphosa apophysis (Goliath pinkfoot tarantula) (Pseudotheraphosa apophysis)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
Gating-modifier toxin that inhibits both sodium (Nav) and calcium (Cav3) channels by inducing hyperpolarizing shift in voltage-dependence of activation and steady state inactivation. Inhibits Nav1.1/SCN1A, Nav1.2/SCN2A, Nav1.6/SCN6A, Nav1.7/SCN9A and Cav3.1/CACNA1G sodium and calcium channels at nanomolar concentrations (IC(50)=169-621 nM).
Mu/omega-theraphotoxin-Tap2a (Mu/omega-TRTX-Tap2a)
spider
Neurotoxin 10 (Hwtx-1) family, 59 (Tltx) subfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:32826759}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 59 (Tltx) subfamily
Mu/omega-theraphotoxin-Tap2a (Mu/omega-TRTX-Tap2a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:32826759}.
spider