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Peptide record

TPDB40381

Neurotoxin Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB40381
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
DCLKFGWKCNPRNDKCCSGLKCGSNHNWCKLHL
Physicochemical Analysis
C162H251N51O44S6
AEQIMTYV
C
3809.45
8.59
8
2
7
+4
4.05
-0.745
47.27
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
11375
298.60
12
Residue Composition
number
0
A
1
R
4
N
2
D
6
C
0
E
0
Q
3
G
2
H
0
I
4
L
5
K
0
M
1
F
1
P
2
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 4 D: 2 C: 6 E: 0 Q: 0 G: 3 H: 2 I: 0 L: 4 K: 5 M: 0 F: 1 P: 1 S: 2 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
33
C162H251N51O44S6
3809.45
8.59
+4
4.05
-0.745
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Voltage-gated sodium channel Nav1.7/SCN9A inhibitor. {ECO:0000269|PubMed:25754331}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Bumba pulcherrimaklaasi (Tarantula spider) (Euathlus pulcherrimaklaasi)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Voltage-gated sodium channel Nav1.7/SCN9A inhibitor..
Mu-theraphotoxin-Ep1a (Mu-TRTX-Ep1a)
spider
Neurotoxin 10 (Hwtx-1) family, 22 (Htx-4) subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:25754331}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 22 (Htx-4) subfamily
Mu-theraphotoxin-Ep1a (Mu-TRTX-Ep1a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:25754331}.
spider