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Peptide record

TPDB40380

Neurotoxin Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB40380
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
ECLGWMKGCEPKNNKCCSSYVCTYKYPWCRYDL
Physicochemical Analysis
C174H256N44O49S7
AQHIF
C
3972.63
8.01
5
3
10
+2
2.02
-0.673
32.42
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
17335
436.36
15
Residue Composition
number
0
A
1
R
2
N
1
D
6
C
2
E
0
Q
2
G
0
H
0
I
2
L
4
K
1
M
0
F
2
P
2
S
1
T
2
W
4
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 2 D: 1 C: 6 E: 2 Q: 0 G: 2 H: 0 I: 0 L: 2 K: 4 M: 1 F: 0 P: 2 S: 2 T: 1 W: 2 Y: 4 V: 1
Chemical Descriptors
33
C174H256N44O49S7
3972.63
8.01
+2
2.02
-0.673
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Voltage-gated sodium channel Nav1.7/SCN9A inhibitor. {ECO:0000269|PubMed:25754331}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Orphnaecus sp. (strain Maanghit-Cave/Philippines) (Tarantula spider)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Voltage-gated sodium channel Nav1.7/SCN9A inhibitor..
Mu-theraphotoxin-Osp1b (Mu-TRTX-Osp1b)
spider
Neurotoxin 10 (Hwtx-1) family, 22 (Htx-4) subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:25754331}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 22 (Htx-4) subfamily
Mu-theraphotoxin-Osp1b (Mu-TRTX-Osp1b)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:25754331}.
spider