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Peptide record

TPDB40379

Neurotoxin Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB40379
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
GCKGFGKACKYGADECCKNLVCSKKHKWCKYTL
Physicochemical Analysis
C161H255N45O43S6
RQIMP
K
3701.43
9.15
9
2
9
+6
5.17
-0.555
38.48
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
8855
239.23
11
Residue Composition
number
2
A
0
R
1
N
1
D
6
C
1
E
0
Q
4
G
1
H
0
I
2
L
8
K
0
M
1
F
0
P
1
S
1
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 1 C: 6 E: 1 Q: 0 G: 4 H: 1 I: 0 L: 2 K: 8 M: 0 F: 1 P: 0 S: 1 T: 1 W: 1 Y: 2 V: 1
Chemical Descriptors
33
C161H255N45O43S6
3701.43
9.15
+6
5.17
-0.555
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Voltage-gated sodium channel Nav1.7/SCN9A inhibitor. {ECO:0000269|PubMed:25754331}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Orphnaecus sp. (strain Sibaliw/Philippines) (Tarantula spider)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Voltage-gated sodium channel Nav1.7/SCN9A inhibitor..
Mu-theraphotoxin-Osp1a (Mu-TRTX-Osp1a)
spider
Neurotoxin 10 (Hwtx-1) family
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:25754331}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family
Mu-theraphotoxin-Osp1a (Mu-TRTX-Osp1a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:25754331}.
spider