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Peptide record

TPDB40377

Neurotoxin Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB40377
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
GCTKFMGSCKTDADCCEHLECYKYKWCGWDGTF
Physicochemical Analysis
C165H235N41O50S7
RNQIPV
C
3817.35
5.41
5
5
9
-1
3.00
-0.518
14.85
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
14355
376.05
12
Residue Composition
number
1
A
0
R
0
N
3
D
6
C
2
E
0
Q
4
G
1
H
0
I
1
L
4
K
1
M
2
F
0
P
1
S
3
T
2
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 3 C: 6 E: 2 Q: 0 G: 4 H: 1 I: 0 L: 1 K: 4 M: 1 F: 2 P: 0 S: 1 T: 3 W: 2 Y: 2 V: 0
Chemical Descriptors
33
C165H235N41O50S7
3817.35
5.41
-1
3.00
-0.518
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Gating-modifier toxin with very weak activity on Nav1.7/SCN9A and Nav1.8/SCN10A. Shows 22% peak current inhibition (at 10 uM) on Nav1.8/SCN10A sodium channels. Show peak current inhibition and delays fast inactivation on Nav1.7/SCN9A (EC(50)>10 uM). {ECO:0000269|PubMed:32092883}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Poecilotheria metallica (Metallic blue ornamental tree spider)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Gating-modifier toxin with very weak activity on Nav1.7/SCN9A and Nav1.8/SCN10A. Shows 22% peak current inhibition (at 10 uM) on Nav1.8/SCN10A sodium channels.
Mu/delta-theraphotoxin-Pm2a (Mu/delta-TRTX-Pm2a) (Delta/mu-theraphotoxin-Pm2a)
spider
Neurotoxin 10 (Hwtx-1) family, 47 subfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:32092883}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 47 subfamily
Mu/delta-theraphotoxin-Pm2a (Mu/delta-TRTX-Pm2a) (Delta/mu-theraphotoxin-Pm2a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:32092883}.
spider