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Peptide record

TPDB40348

Neurotoxin Toxicity standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB40348
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 32-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
ADNKFENSLRREIACGQCRDKVKCDPYFYHCG
Physicochemical Analysis
C160H245N49O49S4
MTW
C
3767.24
7.84
7
5
9
+1
9.87
-0.953
39.69
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
3230
85.74
10
Residue Composition
number
2
A
3
R
2
N
3
D
4
C
2
E
1
Q
2
G
1
H
1
I
1
L
3
K
0
M
2
F
1
P
1
S
0
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 2 R: 3 N: 2 D: 3 C: 4 E: 2 Q: 1 G: 2 H: 1 I: 1 L: 1 K: 3 M: 0 F: 2 P: 1 S: 1 T: 0 W: 0 Y: 2 V: 1
Chemical Descriptors
32
C160H245N49O49S4
3767.24
7.84
+1
9.87
-0.953
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Toxin that specifically inhibits tetrodotoxin-sensitive voltage-gated sodium channels (Nav) (IC(50) of =about 9 nM). In vivo, insects injected with this toxin showed signs of neurotoxicity including twitching, paralysis, and body contraction. {ECO:0000269|PubMed:22595790}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Scolopendra mutilans (Chinese red-headed centipede) (Scolopendra subspinipes mutilans)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Toxin that specifically inhibits tetrodotoxin-sensitive voltage-gated sodium channels (Nav) (IC(50) of =about 9 nM). In vivo, insects injected with this toxin showed signs of neurotoxicity including twitching, paralysis, and body contraction..
Mu-scoloptoxin(03)-Ssm3a (Mu-SLPTX(03)-Ssm3a) (Mu-scoloptoxin-Ssm1a) (Mu-SLPTX-Ssm1a)
other
Scoloptoxin-03 family
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:22595790}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Scoloptoxin-03 family
Mu-scoloptoxin(03)-Ssm3a (Mu-SLPTX(03)-Ssm3a) (Mu-scoloptoxin-Ssm1a) (Mu-SLPTX-Ssm1a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:22595790}.
other