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Peptide record

TPDB40346

Neurotoxin Toxicity standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB40346
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 32-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
CGGAGAKCSTKSDCCSGLWCSGSGHCYHRRYT
Physicochemical Analysis
C134H205N45O44S6
NEQIMFPV
CG
3342.74
8.31
6
1
6
+3
1.67
-0.488
18.44
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
8855
264.90
15
Residue Composition
number
2
A
2
R
0
N
1
D
6
C
0
E
0
Q
6
G
2
H
0
I
1
L
2
K
0
M
0
F
0
P
5
S
2
T
1
W
2
Y
0
V
Amino Acid Distribution
A: 2 R: 2 N: 0 D: 1 C: 6 E: 0 Q: 0 G: 6 H: 2 I: 0 L: 1 K: 2 M: 0 F: 0 P: 0 S: 5 T: 2 W: 1 Y: 2 V: 0
Chemical Descriptors
32
C134H205N45O44S6
3342.74
8.31
+3
1.67
-0.488
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Reversibly inhibits acid-sensing ion channels (ASIC) in rat dorsal root ganglia neurons. Reversibly inhibits voltage-gated potassium channels (Kv) in rat DRG neurons. {ECO:0000250|UniProtKB:C0HJB1}.

Target

voltage-gated sodium channel (Nav) voltage-gated potassium channel (Kv) proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Anthopleura cascaia (Sea anemone)
Neurotoxin Ion channel impairing toxin Proton-gated sodium channel impairing toxin
Reversibly inhibits acid-sensing ion channels (ASIC) in rat dorsal root ganglia neurons. Reversibly inhibits voltage-gated potassium channels (Kv) in rat DRG neurons..
Acatoxin 1 (Acatx1)
sea anemone
Evidence at protein level
3D-structure Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Proton-gated sodium channel impairing toxin Secreted Toxin
Additional Detail Fields 5 fields
3D-structure Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Proton-gated sodium channel impairing toxin Secreted Toxin
Neurotoxin Ion channel impairing toxin Proton-gated sodium channel impairing toxin
Evidence at protein level
Acatoxin 1 (Acatx1)
sea anemone