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Peptide record

TPDB40345

Neurotoxin Toxicity standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB40345
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 32-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
VRDAYIAKPENCVYHCAGNEGCNNLCTCNGAT
Physicochemical Analysis
C138H215N43O48S5
QMFSW
NC
3404.78
5.34
3
3
10
-1
6.40
-0.312
55.00
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
3230
94.87
14
Residue Composition
number
4
A
1
R
5
N
1
D
5
C
2
E
0
Q
3
G
1
H
1
I
1
L
1
K
0
M
0
F
1
P
0
S
2
T
0
W
2
Y
2
V
Amino Acid Distribution
A: 4 R: 1 N: 5 D: 1 C: 5 E: 2 Q: 0 G: 3 H: 1 I: 1 L: 1 K: 1 M: 0 F: 0 P: 1 S: 0 T: 2 W: 0 Y: 2 V: 2
Chemical Descriptors
32
C138H215N43O48S5
3404.78
5.34
-1
6.40
-0.312
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin dose-dependently delays inactivation of voltage-gated sodium channels (Nav) (EC(50)=0.91 uM), and shifts the steady-state activation and inactivation to hyperpolarized direction. In addition, it dose-dependently alters calcium dynamics and increases phosphorylation of MAP kinases 1/3 (MAPK1/MAPK3) and cAMP-response element binding (CREB) proteins in neocortical neurons. This effect is eliminated by tetrodotoxin, a Nav blocker. {ECO:0000269|PubMed:28591591}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Olivierus martensii (Manchurian scorpion) (Mesobuthus martensii)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin dose-dependently delays inactivation of voltage-gated sodium channels (Nav) (EC(50)=0.91 uM), and shifts the steady-state activation and inactivation to hyperpolarized direction.
Sodium channel neurotoxin BmK NT2 (Alpha-scorpion toxin)
scorpion
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Alpha subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:28591591}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Alpha subfamily
Sodium channel neurotoxin BmK NT2 (Alpha-scorpion toxin)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:28591591}.
scorpion