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Peptide record

TPDB40344

Neurotoxin Toxicity standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB40344
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 32-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
DCLGWMAGCDFNDNKCCAGYVCKKHPWCRYDL
Physicochemical Analysis
C160H232N44O45S7
EQIST
C
3716.29
6.75
5
4
11
-0
1.21
-0.391
39.69
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
14355
386.27
10
Residue Composition
number
2
A
1
R
2
N
4
D
6
C
0
E
0
Q
3
G
1
H
0
I
2
L
3
K
1
M
1
F
1
P
0
S
0
T
2
W
2
Y
1
V
Amino Acid Distribution
A: 2 R: 1 N: 2 D: 4 C: 6 E: 0 Q: 0 G: 3 H: 1 I: 0 L: 2 K: 3 M: 1 F: 1 P: 1 S: 0 T: 0 W: 2 Y: 2 V: 1
Chemical Descriptors
32
C160H232N44O45S7
3716.29
6.75
-0
1.21
-0.391
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Voltage-gated sodium channel Nav1.7/SCN9A inhibitor. {ECO:0000269|PubMed:25754331}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Selenocosmia effera (Tarantula spider)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Voltage-gated sodium channel Nav1.7/SCN9A inhibitor..
Mu-theraphotoxin-Se1a (Mu-TRTX-Se1a)
spider
Neurotoxin 10 (Hwtx-1) family
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:25754331}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family
Mu-theraphotoxin-Se1a (Mu-TRTX-Se1a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:25754331}.
spider