Back to search

Peptide record

TPDB40328

Antiviral Neurotoxin Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB40328
Antiviral Neurotoxin Toxicity
Anti-infective peptides Toxicity and safety peptides
AVPpred-BWR NTxPred2 ToxinPred 3.0
standard
No
A 31-aa standard natural multi-activity (Antiviral, Neurotoxin, and Toxicity) peptide sequence curated from AVPpred-BWR, NTxPred2, and ToxinPred 3.0, with an available 3D structural model.
Sequence
AACYSSDCRVKCRAMGFSSGKCIDSKCKCYK
Physicochemical Analysis
C139H228N42O43S7
NEQHLPTW
C
3400.02
8.86
7
2
9
+5
4.27
-0.294
31.61
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
3355
98.68
13
Residue Composition
number
3
A
2
R
0
N
2
D
6
C
0
E
0
Q
2
G
0
H
1
I
0
L
5
K
1
M
1
F
0
P
5
S
0
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 3 R: 2 N: 0 D: 2 C: 6 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 0 K: 5 M: 1 F: 1 P: 0 S: 5 T: 0 W: 0 Y: 2 V: 1
Chemical Descriptors
31
C139H228N42O43S7
3400.02
8.86
+5
4.27
-0.294
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks voltage-gated potassium channels rKv1.1/KCNA1, rKv1.2/KCNA2, hKv1.3/KCNA3, rKv1.6/KCNA6 (IC(50)=75.9 nM) and, to a lesser extent, Shaker IR (with the inactivation domain removed). {ECO:0000269|PubMed:26398235}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Buthus occitanus tunetanus (Common European scorpion) (Buthus tunetanus)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks voltage-gated potassium channels rKv1.1/KCNA1, rKv1.2/KCNA2, hKv1.3/KCNA3, rKv1.6/KCNA6 (IC(50)=75.9 nM) and, to a lesser extent, Shaker IR (with the inactivation domain removed)..
Potassium channel toxin alpha-KTx 19.2 (Toxin Kbot21)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 19 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:26398235}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 19 subfamily
Potassium channel toxin alpha-KTx 19.2 (Toxin Kbot21)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:26398235}.
scorpion