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Peptide record

TPDB40320

Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB40320
Toxicity
Toxicity and safety peptides
ToxinPred 3.0
standard
No
A 30-aa standard natural toxicity peptide sequence curated from ToxinPred 3.0, with an available 3D structural model.
Sequence
GIPCAESCVYIPCTVTALLGCSCSDKVCYN
Physicochemical Analysis
C131H210N32O43S6
RQHMFW
C
3113.66
4.07
1
2
11
-1
1.06
0.767
87.67
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3355
107.75
14
Residue Composition
number
2
A
0
R
1
N
1
D
6
C
1
E
0
Q
2
G
0
H
2
I
2
L
1
K
0
M
0
F
2
P
3
S
2
T
0
W
2
Y
3
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 1 C: 6 E: 1 Q: 0 G: 2 H: 0 I: 2 L: 2 K: 1 M: 0 F: 0 P: 2 S: 3 T: 2 W: 0 Y: 2 V: 3
Chemical Descriptors
30
C131H210N32O43S6
3113.66
4.07
-1
1.06
0.767
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Cytotoxicity
Toxicity
1.71±0.04 µM
Cytotoxic
50% Cytotoxicity | 1.71±0.04 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Discovery and mechanistic studies of cytotoxic cyclotides from the medicinal herb Hybanthus enneaspermus | J Biol Chem | 2020
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>50 µM
Hemolytic Cytotoxic
50% Hemolysis | >50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Discovery and mechanistic studies of cytotoxic cyclotides from the medicinal herb Hybanthus enneaspermus | J Biol Chem | 2020
Evidence 3 Activity

Activity

HC50
Toxicity
50 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human red blood cells (hRBCs): HC50>50 µM | Cytotoxicity: HUVEC: CC50=2.06±0.08 µM , testing time is 24h

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2020 Aug 7 295(32):10911-10925.