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Peptide record

TPDB40317

Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB40317
Toxicity
Toxicity and safety peptides
ToxinPred 3.0
standard
No
A 30-aa standard natural toxicity peptide sequence curated from ToxinPred 3.0, with an available 3D structural model.
Sequence
GVPCGESCVYIPCFTGIINCSCRDKVCYNN
Physicochemical Analysis
C137H213N37O43S6
AQHLMW
C
3258.78
5.97
2
2
9
-0
2.47
0.290
68.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3355
102.95
14
Residue Composition
number
0
A
1
R
3
N
1
D
6
C
1
E
0
Q
3
G
0
H
3
I
0
L
1
K
0
M
1
F
2
P
2
S
1
T
0
W
2
Y
3
V
Amino Acid Distribution
A: 0 R: 1 N: 3 D: 1 C: 6 E: 1 Q: 0 G: 3 H: 0 I: 3 L: 0 K: 1 M: 0 F: 1 P: 2 S: 2 T: 1 W: 0 Y: 2 V: 3
Chemical Descriptors
30
C137H213N37O43S6
3258.78
5.97
-0
2.47
0.290
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Cytotoxicity
Toxicity
2.06±0.08 µM
Cytotoxic
50% Cytotoxicity | 2.06±0.08 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Discovery and mechanistic studies of cytotoxic cyclotides from the medicinal herb Hybanthus enneaspermus | J Biol Chem | 2020
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>50 µM
Hemolytic Cytotoxic
50% Hemolysis | >50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Discovery and mechanistic studies of cytotoxic cyclotides from the medicinal herb Hybanthus enneaspermus | J Biol Chem | 2020
Evidence 3 Activity

Activity

HC50
Toxicity
50 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human red blood cells (hRBCs): HC50>50 µM | Cytotoxicity: HUVEC: CC50=2.06±0.08 µM , testing time is 24h

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2020 Aug 7 295(32):10911-10925.