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Peptide record

TPDB40315

Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB40315
Toxicity
Toxicity and safety peptides
ToxinPred 3.0
standard
No
A 30-aa standard natural toxicity peptide sequence curated from ToxinPred 3.0, with an available 3D structural model.
Sequence
GFPCGESCVYIPCFTAAIGCSCKSKVCYKN
Physicochemical Analysis
C138H212N34O40S6
RDQHLMW
C
3179.77
8.01
3
1
10
+2
0.47
0.427
52.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3355
105.51
13
Residue Composition
number
2
A
0
R
1
N
0
D
6
C
1
E
0
Q
3
G
0
H
2
I
0
L
3
K
0
M
2
F
2
P
3
S
1
T
0
W
2
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 6 E: 1 Q: 0 G: 3 H: 0 I: 2 L: 0 K: 3 M: 0 F: 2 P: 2 S: 3 T: 1 W: 0 Y: 2 V: 2
Chemical Descriptors
30
C138H212N34O40S6
3179.77
8.01
+2
0.47
0.427
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Cytotoxicity
Toxicity
0.62±0.01 µM
Cytotoxic
50% Cytotoxicity | 0.62±0.01 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Discovery and mechanistic studies of cytotoxic cyclotides from the medicinal herb Hybanthus enneaspermus | J Biol Chem | 2020
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
24.56±2.16 µM
Hemolytic Cytotoxic
50% Hemolysis | 24.56±2.16 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Discovery and mechanistic studies of cytotoxic cyclotides from the medicinal herb Hybanthus enneaspermus | J Biol Chem | 2020
Evidence 3 Activity

Activity

HC50
Toxicity
24.56
Hemolytic Cytotoxic
Hemolytic_activity: Human red blood cells (hRBCs): HC50=24.56±2.16 µM | Cytotoxicity: HUVEC:CC50=0.62±0.01 µM, testing time is 24h

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2020 Aug 7 295(32):10911-10925.