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Peptide record

TPDB40290

Neurotoxin Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB40290
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
SCQKWMWTCDQKRPCCEDMVCKLWCKIIK
Physicochemical Analysis
C155H246N42O40S8
ANGHFY
C
3594.40
8.31
6
3
9
+3
3.56
-0.397
50.34
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
16875
469.48
10
Residue Composition
number
0
A
1
R
0
N
2
D
6
C
1
E
2
Q
0
G
0
H
2
I
1
L
5
K
2
M
0
F
1
P
1
S
1
T
3
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 2 C: 6 E: 1 Q: 2 G: 0 H: 0 I: 2 L: 1 K: 5 M: 2 F: 0 P: 1 S: 1 T: 1 W: 3 Y: 0 V: 1
Chemical Descriptors
29
C155H246N42O40S8
3594.40
8.31
+3
3.56
-0.397
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits mammalian and insect voltage-gated sodium and potassium voltage-gated channels. Inhibits the mammalian sodium channels rNav1.2/SCN2A, rNav1.3/SCN3A, rNav1.4/SCN4A, hNav1.5/SCN5A, mNav1.6/SCN8A (IC(50)=156.39 nM), hNav1.8/SCN10A, the arachnid sodium channel VdNav (IC(50)=124.05 nM), as well as the potassium channels Kv11.1/KCNH2/ERG1 (IC(50)=3.7 uM) and rKv4.3/KCND3. In vivo, is lethal on insects (tested on flies M.domestica). When tested on mice, it shows very low toxicity, causing reversible paralyzes at the first hour after intracerebroventricular injection. {ECO:0000269|PubMed:32717411}.

Target

voltage-gated sodium channel (Nav) voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Grammostola iheringi (Argentinean black tarantula) (Eurypelma iheringii)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Inhibits mammalian and insect voltage-gated sodium and potassium voltage-gated channels. Inhibits the mammalian sodium channels rNav1.2/SCN2A, rNav1.3/SCN3A, rNav1.4/SCN4A, hNav1.5/SCN5A, mNav1.6/SCN8A (IC(50)=156.39 nM), hNav1.8/SCN10A, the arachnid sodium channel VdNav (IC(50)=124.05 nM), as well as the potassium channels Kv11.1/KCNH2/ERG1 (IC(50)=3.7 uM) and rKv4.3/KCND3.
Beta/kappa-theraphotoxin-Gi1a (Beta/kappa-TRTX-Gi1a) (GiTx1)
spider
Phrixotoxin family
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:32717411}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Phrixotoxin family
Beta/kappa-theraphotoxin-Gi1a (Beta/kappa-TRTX-Gi1a) (GiTx1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:32717411}.
spider