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Peptide record

TPDB40288

Neurotoxin Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB40288
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
CIPAANPCRGNARCCGNYVCKNGRCLPRS
Physicochemical Analysis
C123H206N46O36S6
DEQHMFTW
C
3097.64
8.92
5
0
7
+5
3.73
-0.383
47.24
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
1865
60.21
12
Residue Composition
number
3
A
4
R
4
N
0
D
6
C
0
E
0
Q
3
G
0
H
1
I
1
L
1
K
0
M
0
F
3
P
1
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 3 R: 4 N: 4 D: 0 C: 6 E: 0 Q: 0 G: 3 H: 0 I: 1 L: 1 K: 1 M: 0 F: 0 P: 3 S: 1 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
29
C123H206N46O36S6
3097.64
8.92
+5
3.73
-0.383
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds reversibly and blocks P/Q-type voltage-gated calcium channels (Cav). {ECO:0000250|UniProtKB:P58608}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Platymeris biguttatus (Two-spotted assassin bug)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Binds reversibly and blocks P/Q-type voltage-gated calcium channels (Cav)..
U-reduvitoxin-Pbi1a (U-RDTX-Pbi1a) (Pbi1a)
insect
Venom Ptu1-like knottin family
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Venom Ptu1-like knottin family
U-reduvitoxin-Pbi1a (U-RDTX-Pbi1a) (Pbi1a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
insect