Back to search

Peptide record

TPDB40257

Neurotoxin Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB40257
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
YCQKFLWTCDSERPCCEGLVCRLWCKIN
Physicochemical Analysis
C148H226N40O40S6
AHM
C
3398.03
7.62
4
3
9
+1
1.47
-0.107
66.07
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
12865
378.60
11
Residue Composition
number
0
A
2
R
1
N
1
D
6
C
2
E
1
Q
1
G
0
H
1
I
3
L
2
K
0
M
1
F
1
P
1
S
1
T
2
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 1 D: 1 C: 6 E: 2 Q: 1 G: 1 H: 0 I: 1 L: 3 K: 2 M: 0 F: 1 P: 1 S: 1 T: 1 W: 2 Y: 1 V: 1
Chemical Descriptors
28
C148H226N40O40S6
3398.03
7.62
+1
1.47
-0.107
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potent and selective inhibitor of Nav1.7/SCN9A sodium channels. Inhibits Nav1.7/SCN9A peak current (IC(50)=13 nM) (PubMed:31647222). In vivo, does not induce visible signs of toxicity when intravenously injected into mice (PubMed:31647222). {ECO:0000269|PubMed:31647222}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Homoeomma sp. (Peruvian tarantula)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Potent and selective inhibitor of Nav1.7/SCN9A sodium channels. Inhibits Nav1.7/SCN9A peak current (IC(50)=13 nM) (PubMed:31647222).
Mu-theraphotoxin-Hsp1a (Hsp1a) (Mu-TRTX-Hsp1a)
spider
Neurotoxin 30 (phrixotoxin) family
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:31647222}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 30 (phrixotoxin) family
Mu-theraphotoxin-Hsp1a (Hsp1a) (Mu-TRTX-Hsp1a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:31647222}.
spider