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Peptide record

TPDB40192

Neurotoxin Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB40192
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
RICLNQQSSEPQTTEICPDGEDTCY
Physicochemical Analysis
C114H180N32O46S3
AHKMFWV
CEQT
2831.05
3.50
1
5
4
-4
10.24
-0.972
46.80
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1615
57.05
13
Residue Composition
number
0
A
1
R
1
N
2
D
3
C
3
E
3
Q
1
G
0
H
2
I
1
L
0
K
0
M
0
F
2
P
2
S
3
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 2 C: 3 E: 3 Q: 3 G: 1 H: 0 I: 2 L: 1 K: 0 M: 0 F: 0 P: 2 S: 2 T: 3 W: 0 Y: 1 V: 0
Chemical Descriptors
25
C114H180N32O46S3
2831.05
3.50
-4
10.24
-0.972
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission. {ECO:0000269|PubMed:24440452}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Bungarus fasciatus (Banded krait) (Pseudoboa fasciata)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission..
Alpha-elapitoxin-Bf1b (Alpha-EPTX-Bf1b)
snake
Three-finger toxin family, Short-chain subfamily, Type I alpha-neurotoxin sub-subfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:24440452}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Three-finger toxin family, Short-chain subfamily, Type I alpha-neurotoxin sub-subfamily
Alpha-elapitoxin-Bf1b (Alpha-EPTX-Bf1b)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:24440452}.
snake