Back to search

Peptide record

TPDB40149

Neurotoxin Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB40149
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 23-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
GCRQCGGGCNKHGKCINGKCKCY
Physicochemical Analysis
C94H157N35O28S6
ADELMFPSTWV
CG
2417.86
8.89
6
0
2
+5
4.52
-0.783
16.96
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1865
77.13
10
Residue Composition
number
0
A
1
R
2
N
0
D
6
C
0
E
1
Q
6
G
1
H
1
I
0
L
4
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 2 D: 0 C: 6 E: 0 Q: 1 G: 6 H: 1 I: 1 L: 0 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
23
C94H157N35O28S6
2417.86
8.89
+5
4.52
-0.783
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: May block voltage-gated potassium channels (Kv). {ECO:0000305}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Tityus stigmurus (Brazilian scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
May block voltage-gated potassium channels (Kv)..
Peptide 2412 (Potassium channel toxin alpha-KTx)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:17270501}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family
Peptide 2412 (Potassium channel toxin alpha-KTx)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:17270501}.
scorpion