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Peptide record

TPDB40148

Neurotoxin Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB40148
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 23-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
CKCPSCNFNDVTENCKCCIFRQP
Physicochemical Analysis
C108H170N32O34S6
AGHLMWY
C
2653.09
7.63
3
2
4
+1
5.11
-0.378
29.57
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
375
14.13
12
Residue Composition
number
0
A
1
R
3
N
1
D
6
C
1
E
1
Q
0
G
0
H
1
I
0
L
2
K
0
M
2
F
2
P
1
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 3 D: 1 C: 6 E: 1 Q: 1 G: 0 H: 0 I: 1 L: 0 K: 2 M: 0 F: 2 P: 2 S: 1 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
23
C108H170N32O34S6
2653.09
7.63
+1
5.11
-0.378
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Upon intracranial injection in mice, as25a (the toxin without the two 4-hydroxyprolines) provokes paralysis of the hind limbs and death with a dose of 240 pmol. {ECO:0000269|PubMed:23474143}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus cancellatus (Cancellate cone) (Conus austini)
Neurotoxin
Upon intracranial injection in mice, as25a (the toxin without the two 4-hydroxyprolines) provokes paralysis of the hind limbs and death with a dose of 240 pmol..
Conotoxin as25a (As25b)
cone snail
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Hydroxylation Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:23474143}.
Additional Detail Fields 6 fields
Amidation Direct protein sequencing Disulfide bond Hydroxylation Neurotoxin Secreted Toxin
Neurotoxin
Evidence at protein level
Conotoxin as25a (As25b)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:23474143}.
cone snail