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Peptide record

TPDB40132

Neurotoxin Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB40132
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 10-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
GFRSPCPPFC
Physicochemical Analysis
C50H71N13O12S2
ANDEQHILKMTWYV
P
1110.31
8.30
1
0
2
+1
-0.44
0.010
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
11.26
3
Residue Composition
number
0
A
1
R
0
N
0
D
2
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
2
F
3
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 2 P: 3 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C50H71N13O12S2
1110.31
8.30
+1
-0.44
0.010
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits the human alpha-3-beta-4/CHRNA3-CHRNB4 (IC(50)=15.7 uM) and alpha-7/CHRNA7 (IC(50)=77.2 uM) nicotinic acetylcholine receptor (nAChR) (PubMed:32234761). Incomplete inhibition of responses is observed for both subtypes, indicating a potential non-competitive mode of action (PubMed:32234761). {ECO:0000269|PubMed:32234761}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus zonatus (Zoned cone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin
Inhibits the human alpha-3-beta-4/CHRNA3-CHRNB4 (IC(50)=15.7 uM) and alpha-7/CHRNA7 (IC(50)=77.2 uM) nicotinic acetylcholine receptor (nAChR) (PubMed:32234761). Incomplete inhibition of responses is observed for both subtypes, indicating a potential non-competitive mode of action (PubMed:32234761)..
Conotoxin Czon1107
cone snail
Evidence at protein level
3D-structure Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:32234761}.
Additional Detail Fields 6 fields
3D-structure Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin
Evidence at protein level
Conotoxin Czon1107
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:32234761}.
cone snail