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Peptide record

TPDB40129

Neurotoxin Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB40129
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 22-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
GEEERKAMAELEAKKAQEALKA
Physicochemical Analysis
C102H176N30O36S1
NDCHIFPSTWYV
AE
2430.76
4.95
5
6
9
-1
15.11
-1.123
62.73
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
6
A
1
R
0
N
0
D
0
C
6
E
1
Q
1
G
0
H
0
I
2
L
4
K
1
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 6 R: 1 N: 0 D: 0 C: 0 E: 6 Q: 1 G: 1 H: 0 I: 0 L: 2 K: 4 M: 1 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
22
C102H176N30O36S1
2430.76
4.95
-1
15.11
-1.123
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors. {ECO:0000250}.

Target

glutamate receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus ochroleucus (Perfect cone) (Graphiconus ochroleucus)
Neurotoxin Postsynaptic neurotoxin Ion channel impairing toxin Ionotropic glutamate receptor inhibitor
Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors..
Conantokin-Oc (Con-Oc)
cone snail
Evidence at protein level
Gamma-carboxyglutamic acid Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305}.
Additional Detail Fields 6 fields
Gamma-carboxyglutamic acid Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Ion channel impairing toxin Ionotropic glutamate receptor inhibitor
Evidence at protein level
Conantokin-Oc (Con-Oc)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305}.
cone snail