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Peptide record

TPDB40126

Neurotoxin Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB40126
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 10-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
QNECPWKPWC
Physicochemical Analysis
C58H79N15O15S2
ARDGHILMFSTYV
CPW
1290.48
6.14
1
1
2
-0
0.73
-1.440
0.00
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
11125
862.08
4
Residue Composition
number
0
A
0
R
1
N
0
D
2
C
1
E
1
Q
0
G
0
H
0
I
0
L
1
K
0
M
0
F
2
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 2 E: 1 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 2 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
10
C58H79N15O15S2
1290.48
6.14
-0
0.73
-1.440
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Its target is unknown, but this toxin may modulate voltage-activated calcium channels (Cav) or calcium-dependent potassium channels (KCa). {ECO:0000250|UniProtKB:P0C248, ECO:0000250|UniProtKB:P0C250, ECO:0000250|UniProtKB:P62903, ECO:0000250|UniProtKB:P83047}.

Target

voltage-gated potassium channel (Kv) voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus araneosus (Cobweb cone)
Neurotoxin Ion channel impairing toxin
Its target is unknown, but this toxin may modulate voltage-activated calcium channels (Cav) or calcium-dependent potassium channels (KCa)..
Contryphan-Ar3 (Ar1286) (Ar1330)
cone snail
O2 superfamily, Contryphan family
Evidence at protein level
Amidation D-amino acid Direct protein sequencing Disulfide bond Gamma-carboxyglutamic acid Ion channel impairing toxin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:28152596}.
Additional Detail Fields 7 fields
Amidation D-amino acid Direct protein sequencing Disulfide bond Gamma-carboxyglutamic acid Ion channel impairing toxin Neurotoxin Secreted Toxin
Neurotoxin Ion channel impairing toxin
Evidence at protein level
O2 superfamily, Contryphan family
Contryphan-Ar3 (Ar1286) (Ar1330)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:28152596}.
cone snail